{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T07:49:31Z","timestamp":1782719371151,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Discovery"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Renal fibrosis is a common pathological feature and key driver of progression to end\u2010stage renal disease in various chronic kidney diseases,\u00a0with effective treatments remaining scarce. Exosomes derived from mesenchymal stem cells (MSC\u2010Exos) have demonstrated tremendous potential in tissue and organ repair and antifibrosis treatment. This study investigated the therapeutic effects and mechanisms of MSC\u2010Exo derived from human umbilical cord (HucMSC\u2010Exo) on renal fibrosis. HucMSC\u2010Exo was applied to intervene in a mouse model of renal fibrosis induced by unilateral ureteral obstruction (UUO) or cocultured with TGF\u2010\u03b2\u2010stimulated rat renal fibroblasts (NRK\u201049F). Results showed that HucMSC\u2010Exo conspicuously alleviated pathological damage, inflammatory response, fibroblast proliferation\/activation, and extracellular matrix deposition in UUO kidneys. Single\u2010cell sequencing revealed a prominent upregulation of\n                    <jats:italic>Inhba<\/jats:italic>\n                    gene in UUO kidneys, whereas HucMSC\u2010Exo treatment effectively inhibited its expression. Further mechanistic studies showed that knocking down\n                    <jats:italic>Inhba<\/jats:italic>\n                    mimicked the antifibrotic effects of HucMSC\u2010Exo, whereas exogenously adding INHBA weakened its protective effects. Transcriptome sequencing results revealed that the downstream effects of\n                    <jats:italic>Inhba<\/jats:italic>\n                    involve regulating the PI3K\/AKT signaling pathway, and HucMSC\u2010Exo treatment markedly inhibited the activation of this pathway. Collectively, HucMSC\u2011Exo exerts antifibrotic effects by regulating the INHBA\/PI3K\/AKT signaling axis to inhibit renal fibroblast activation.\n                  <\/jats:p>","DOI":"10.1002\/pdi3.70061","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T07:41:54Z","timestamp":1782718914000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Human Umbilical Cord Mesenchymal Stem Cell\u2013Derived Exosomes Attenuate Renal Fibrosis by Suppressing Fibroblast Activation via the INHBA\/PI3K\/AKT Pathway"],"prefix":"10.1002","author":[{"given":"Meiling","family":"Chen","sequence":"first","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders, Department of Urology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Structural Birth Defect and Reconstruction  Chongqing China"},{"name":"Children Urogenital Development and Tissue Engineering of Chongqing Education Commission of China  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Jia","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders, Department of Urology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Structural Birth Defect and Reconstruction  Chongqing China"},{"name":"Children Urogenital Development and Tissue Engineering of Chongqing Education Commission of China  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuocheng","family":"Shi","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders, Department of Urology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Structural Birth Defect and Reconstruction  Chongqing China"},{"name":"Children Urogenital Development and Tissue Engineering of Chongqing Education Commission of China  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders, Department of Urology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Structural Birth Defect and Reconstruction  Chongqing China"},{"name":"Children Urogenital Development and Tissue Engineering of Chongqing Education Commission of China  Chongqing 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Structural Birth Defect and Reconstruction  Chongqing China"},{"name":"Children Urogenital Development and Tissue Engineering of Chongqing Education Commission of China  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Urology West China Second University Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Bio\u2010Intelligent Manufacturing and Living Matter Bioprinting Research Institute of Tsinghua University in Shenzhen, Tsinghua University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[{"name":"Center for Bio\u2010Intelligent Manufacturing and Living Matter Bioprinting Research Institute of Tsinghua University in Shenzhen, Tsinghua University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8488-2967","authenticated-orcid":false,"given":"Deying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders, Department of Urology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and 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