{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T07:29:26Z","timestamp":1793777366206,"version":"4.6.1"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Discovery"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pediatric sepsis remains a significant global health burden with considerable mortality and morbidity, particularly in resource\u2010limited settings. This umbrella review synthesizes current evidence from systematic reviews and meta\u2010analyses on the definitions, epidemiology, diagnostic approaches, prognostic models, and emerging prediction technologies of pediatric sepsis\u00a0worldwide. Through comprehensive evaluation of 18 high\u2010quality systematic reviews published between 2019 and 2024, we identified critical gaps in early recognition and management protocols while highlighting promising technological innovations that demonstrate robust prediction potential. Our analysis revealed substantial variation in sepsis outcomes across different healthcare settings, with approximately 85% of global pediatric sepsis deaths occurring in low\u2010 and middle\u2010income countries (LMICs). Quantitative synthesis of prediction models demonstrated pooled sensitivity of 0.81 (95% confidence interval [CI]: 0.76\u20130.85) and specificity of 0.79 (95% CI: 0.74\u20130.84), with area under the receiver operating characteristic curve\u00a0values ranging from 0.78 to 0.94 depending on resource setting and model complexity. The integration of machine learning algorithms with traditional clinical markers showed particular promise for developing context\u2010appropriate prediction tools that function effectively across resource settings. Etiological analysis revealed distinct pathogen profiles by age and geography: Gram\u2010negative organisms were\u00a0predominant in neonates (68%) and LMICs (72%), while Gram\u2010positive pathogens accounted for 58% of cases in high\u2010income country settings. Antimicrobial resistance exceeded 50% for common pathogens in LMICs, critically complicating empirical treatment. This review provides a comprehensive foundation for future research directions and implementation strategies to reduce the global burden of pediatric sepsis through precision medicine approaches and health system strengthening.<\/jats:p>","DOI":"10.1002\/pdi3.70069","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:26:57Z","timestamp":1790314017000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Umbrella Review for Pediatric Sepsis and Robust Prediction Potential Worldwide"],"prefix":"10.1002","volume":"4","author":[{"given":"Wenbo","family":"Fu","sequence":"first","affiliation":[{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Li","sequence":"additional","affiliation":[{"name":"Children\u2019s Medicine Center The First Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1976-2376","authenticated-orcid":false,"given":"Sheng","family":"Fu","sequence":"additional","affiliation":[{"name":"Asia Pacific Advanced Health and Medical Institution  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20104642(24)00140\u20108"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005294"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(17)30467\u2010X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo\u20102022\u2010001627"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390\u2010021\u201001620\u20105"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20104642(24)00142\u20101"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2024.1463986"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.1433"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41746\u2010024\u201001361\u20109"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.21037\/pm\u201024\u201070"}],"updated-by":[{"DOI":"10.1002\/pdi3.70080","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T00:00:00Z","timestamp":1793664000000}}],"container-title":["Pediatric Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pdi3.70069","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pdi3.70069","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pdi3.70069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T10:45:19Z","timestamp":1792838719000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pdi3.70069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/pdi3.70069"],"URL":"https:\/\/doi.org\/10.1002\/pdi3.70069","archive":["Portico"],"relation":{},"ISSN":["2835-558X","2835-5598"],"issn-type":[{"value":"2835-558X","type":"print"},{"value":"2835-5598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2025-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70069"}}