{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:04:49Z","timestamp":1759334689558,"version":"build-2065373602"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Discovery"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The regimen of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or CHOP with rituximab (R\u2010CHOP) is the first\u2010line treatment for non\u2010Hodgkin lymphoma (NHL). NHL patients treated with CHOP\/R\u2010CHOP have a high risk of reproductive adverse events. The aim of this article was to evaluate the reproductive toxicity of regimens and make further suggestions on reproductive protection. We systematically searched with appropriate terms from January 1980 to June 2021 for observational studies in patients treated with CHOP\/R\u2010CHOP, without any language restriction. We conducted meta\u2010analyses of one\u2010sample proportions of patients suffering reproductive adverse events after using CHOP\/R\u2010CHOP. In addition, subgroup analyses were performed to determine the effect of sex. Nine articles involving 331 patients were included in the meta\u2010analysis, and the pooled proportion of reproductive adverse events was computed to be 22.3% (95% confidence interval [CI] 11.4%\u201333.2%; heterogeneity test <jats:italic>Q<\/jats:italic>\u00a0=\u00a065.3; <jats:italic>\u03c4<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.0231; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a087.70%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) using the random\u2010effects model. And, the pooled proportion of male gonadal toxicity was 29.2% (95% CI 11.0%\u201347.4%; heterogeneity test <jats:italic>Q<\/jats:italic>\u00a0=\u00a046.65; <jats:italic>\u03c4<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a03.055; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a089.3%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). The pooled proportion of female gonadal toxicity was 16.5% (95% CI 8.5%\u201324.5%; heterogeneity test <jats:italic>Q<\/jats:italic>\u00a0=\u00a018.6; <jats:italic>\u03c4<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.0112; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a067.8%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005). The findings suggest that NHL patients have a relatively high risk of reproductive adverse events after treatment with CHOP\/R\u2010CHOP. Men are more likely to have gonadal damage than women. Evaluation of reproductive function is particularly necessary both before and after treatment. Some reproductive protection strategies implemented for patients who want to preserve their fertility.<\/jats:p>","DOI":"10.1002\/pdi3.72","type":"journal-article","created":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T02:15:13Z","timestamp":1716603313000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reproductive adverse events in patients with non\u2010Hodgkin lymphoma treated with chemotherapeutic regimens including cyclophosphamide, doxorubicin, vincristine, prednisone or CHOP with rituximab: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"3","author":[{"given":"Rong","family":"Han","sequence":"first","affiliation":[{"name":"Department of Urology Children's Hospital of Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Structural BirthDefect and Reconstruction  Chongqing China"},{"name":"National Clinical Research Center for Child Health and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Pediatrics Chongqing  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Urology Children's Hospital of Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Structural BirthDefect and Reconstruction  Chongqing China"},{"name":"National Clinical Research Center for Child Health and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Pediatrics Chongqing  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengjun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Urology Children's Hospital of Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Structural BirthDefect and Reconstruction  Chongqing China"},{"name":"National Clinical Research Center for Child Health and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Pediatrics Chongqing  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Children's Hospital of Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Structural BirthDefect and Reconstruction  Chongqing China"},{"name":"National Clinical Research Center for Child Health and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Pediatrics Chongqing  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Children's Hospital of Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Structural BirthDefect and Reconstruction  Chongqing China"},{"name":"National Clinical Research Center for Child Health and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Pediatrics Chongqing  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Urology Children's Hospital of Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Structural BirthDefect and Reconstruction  Chongqing China"},{"name":"National Clinical Research Center for Child Health and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Pediatrics Chongqing  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0083-561X","authenticated-orcid":false,"given":"Shengde","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology Children's Hospital of Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Structural BirthDefect and Reconstruction  Chongqing China"},{"name":"National Clinical Research Center for Child Health and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Pediatrics Chongqing  Chongqing China"},{"name":"Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"key":"e_1_2_20_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304083281404"},{"key":"e_1_2_20_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011795"},{"key":"e_1_2_20_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21637"},{"key":"e_1_2_20_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-82-1-84"},{"key":"e_1_2_20_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-93-1-109"},{"key":"e_1_2_20_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.125028"},{"key":"e_1_2_20_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_20_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.NAJ.0000450430.97383.64"},{"key":"e_1_2_20_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1984.2.8.898"},{"key":"e_1_2_20_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a058519"},{"key":"e_1_2_20_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.2.239"},{"key":"e_1_2_20_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01727413"},{"key":"e_1_2_20_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei018"},{"key":"e_1_2_20_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190500353877"},{"key":"e_1_2_20_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12877"},{"key":"e_1_2_20_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv227"},{"issue":"1","key":"e_1_2_20_18_1","first-page":"16","article-title":"Semen 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