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Soluble CD36 (sCD36), a circulating form of CD36, is identified in human plasma. Current studies have demonstrated that sCD36 is an early biomarker of type 2 diabetes (T2DM) and atherosclerosis risk and may act as a key molecule in organ cross\u2010talks directly or indirectly. This review summarizes the cell sources, molecular structure, potential production mechanism, functions, and regulators of sCD36. We highlight the association of sCD36 with hyperlipidemia, metabolic inflammation, T2DM, cardiovascular disease, non\u2010alcoholic fatty liver disease, diabetic kidney disease, and obesity. These studies suggest that sCD36 could be a useful biomarker for metabolic diseases in children and a potential therapeutic target in preventing metabolic diseases.<\/jats:p>","DOI":"10.1002\/pdi3.9","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T13:43:55Z","timestamp":1686577435000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The association of soluble cluster of differentiation 36 with metabolic diseases: A potential biomarker and therapeutic target"],"prefix":"10.1002","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2808-0626","authenticated-orcid":false,"given":"Yun","family":"Li","sequence":"first","affiliation":[{"name":"Centre for Lipid Research &amp; Chongqing Key Laboratory of Metabolism on Lipid and Glucose The Second Affiliated Hospital Chongqing Medical University  Chongqing 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