{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T22:15:10Z","timestamp":1757456110021},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,26]],"date-time":"2004-10-26T00:00:00Z","timestamp":1098748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To describe the drug utilization pattern among hypertensive patients in a tertiary care setting, assess the short\u2010term outcome of anti\u2010hypertensive drugs usage and identify points for future intervention to improve outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross sectional retrospective drug use review was conducted between 1st June and 31st August 2002 on randomly selected 200 case notes of hypertensive patients at a tertiary care facility in South\u2010Western Nigeria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Diuretics were the most frequently prescribed anti\u2010hypertensive class (39.4%), followed by centrally acting agents (23.3%), calcium channel blockers (21%), angiotensine converting enzyme (ACE) inhibitors (8.6%) and beta blockers (1.9%). Aspirin was the most frequently prescribed adjoining non\u2010anti\u2010hypertensive drugs (39.7%), followed by anxiolytics (23.6%), other non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs) (14.8%), metformin (6.7%), glibenclamide (5.9%), paracetamol (5.9%) and Mist. Magnesium Trisilicate (3.3%). All patients made out\u2010of\u2010pocket payments for their prescribed anti\u2010hypertensive drugs at the study site. Blood pressure control was adequate in only 33.9% of patients. There was no significant difference in blood pressure control between male and female hypertensives (\u2009<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Anti\u2010hypertensive drugs were changed at least once in 44% of patients and blood pressure control was significantly better in patients with at least one change (\u2009<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Adherence with drug therapy was documented as adequate in 82.5% of patient. Diabetes mellitus (NIDDM) (39.6%) and osteoarthritis (22.9%) were the most frequent co\u2010morbidities. Potential harmful drug interactions were identified in 3.8% (49) of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Diuretics and centrally acting agents were the most frequently prescribed anti\u2010hypertensive drugs in a tertiary care setting in Nigeria. Physicians' prescribing decisions appear significantly influenced by cost consideration. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.1035","type":"journal-article","created":{"date-parts":[[2004,11,7]],"date-time":"2004-11-07T16:54:25Z","timestamp":1099846465000},"page":"69-74","source":"Crossref","is-referenced-by-count":12,"title":["Pattern of drug utilization among hypertensives in a Nigerian teaching hospital"],"prefix":"10.1002","volume":"14","author":[{"given":"K. 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