{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:04:11Z","timestamp":1787166251353,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,7,6]],"date-time":"2006-07-06T00:00:00Z","timestamp":1152144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The objective of this study was to quantify rates of adverse events in a high\u2010risk multi\u2010morbid population of institutionalized patients with Alzheimer's disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study among nursing home residents diagnosed with AD and psychosis during January 1998 to October 1999. Using the Medicare Minimum Data Set (MDS) and Medicare inpatient claims (ICD\u20109 codes), 7728 nursing home residents aged 55\u201395 years with AD and psychosis were identified for study. Potential adverse events of interest were identified from the MDS and Medicare inpatient claims (ICD\u20109 codes). We estimated the incidence rate (IR) and 95% confidence interval (CI) for each adverse event during a 2\u2010year follow\u2010up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 7728 residents studied, nearly 30% were considered \u2018dependent\u2019 by the activities of daily living (ADL) score and approximately 15% exhibited severe cognitive impairment at baseline. At least 90% had comorbid psychiatric disorders. The most common adverse event was accidental injury, occurring at a rate of 97.7 per 100 person\u2010years (95%CI\u2009=\u200994.7\u2013100.7). Other common adverse events were death (IR\u2009=\u200944.6\/100 person\u2010years; 95%CI\u2009=\u200942.9\u201346.4), infection (IR\u2009=\u200941.8\/100 person\u2010years; 95%CI\u2009=\u200939.7\u201343.8), pain (IR\u2009=\u200943.5\/100 person\u2010years; 95%CI\u2009=\u200941.2\u201345.9), anorexia (41.3\/100 person\u2010years; 95%CI\u2009=\u200939.1\u201343.6), and weight change (IR\u2009=\u200940.2\/100 person\u2010years; 95%CI\u2009=\u200938.7\u201341.7).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This information on the occurrence of adverse outcomes among nursing home patients with AD and psychosis provides useful context for any safety event observed among patients treated for psychosis. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.1274","type":"journal-article","created":{"date-parts":[[2006,7,6]],"date-time":"2006-07-06T07:22:20Z","timestamp":1152170540000},"page":"763-774","source":"Crossref","is-referenced-by-count":14,"title":["Adverse events among nursing home residents with Alzheimer's disease and psychosis"],"prefix":"10.1002","volume":"15","author":[{"given":"Susan A.","family":"Oliveria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Liperoti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"L'Italien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Pugner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Safferman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Carson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Lapane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.1.115"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.74.12.1381"},{"key":"e_1_2_1_4_2","first-page":"1","article-title":"Current concepts in understanding Alzheimer's Disease","volume":"1","author":"Eggert A","year":"1994","journal-title":"Clin Pharm Newswatch"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0918"},{"key":"e_1_2_1_6_2","volume-title":"The Pharmacological Basis of Therapeutics","author":"Goodman LS","year":"1993"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/30.3.293"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/35.2.172"},{"issue":"6","key":"e_1_2_1_9_2","first-page":"162","article-title":"The potential for using administrative and clinical data to analyze outcomes for the cognitively impaired: an assessment of the Minimum Data Set for Nursing Homes","volume":"11","author":"Phillips CD","year":"1997","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"e_1_2_1_10_2","volume-title":"SAS\/STAT software","author":"SAS Institute I","year":"2002"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1994.tb06070.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199802000-00006"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/32.2.148"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.1274","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.1274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T03:49:50Z","timestamp":1700020190000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.1274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,6]]},"references-count":12,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1002\/pds.1274"],"URL":"https:\/\/doi.org\/10.1002\/pds.1274","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,6]]}}}