{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:54:31Z","timestamp":1790477671156,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,10,30]],"date-time":"2006-10-30T00:00:00Z","timestamp":1162166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the association between opioid use and the occurrence of postoperative paralytic ileus (POI) after different types of surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The PHARMO database was used to perform a case control study in which intramural drug utilisation data were linked to hospital discharge diagnoses. All patients admitted for digestive, abdominal or genito\u2010urinary surgeries were selected in 1998\u20132003. Cases with coded POI (ICD\u20109\u2010CM 560.1 and 564.4) and controls with no POI were matched 1:10. The association between coded POI and opioid use was assessed using conditional logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 0.2% of all admissions (total of 180,279), patients developed POI and in 18% of all admissions, patients received opioids. Three hundred and sixty\u2010six cases with POI were selected with their matching controls. The use of (nico)morphine was associated with the risk for developing POI (odds ratio (OR) 12.1, 95% confidence interval (CI) 5.4\u201327.1). The association between opioids and POI was most obvious in patients with abdominal surgery (OR 33.8, 95%CI 6.2\u2013184.6) and patients without colon\/colorectal\/rectal tumours (OR 13.2, 95%CI 5.7\u201330.3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated a distinct association between the use of opioids, in particular natural opium alkaloids, and the risk for coded POI. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.1338","type":"journal-article","created":{"date-parts":[[2006,10,30]],"date-time":"2006-10-30T19:48:02Z","timestamp":1162237682000},"page":"668-674","source":"Crossref","is-referenced-by-count":44,"title":["In\u2010hospital use of opioids increases rate of coded postoperative paralytic ileus"],"prefix":"10.1002","volume":"16","author":[{"given":"Wim G.","family":"Goettsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrthe P. P.","family":"Sukel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald L.","family":"van der Peet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie M.","family":"van Riemsdijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron M. C.","family":"Herings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,30]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(03)01118-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01595.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(01)00781-4"},{"key":"e_1_2_1_5_2","first-page":"590","article-title":"Clinical and economic outcomes of prolonged postoperative ileus in patients undergoing hysterectomy and hemicolectomy","volume":"30","author":"Salvador CG","year":"2005","journal-title":"P & T"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363070-00003"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199908000-00016"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1097\/01.sla.0000141158.27977.66","article-title":"Alvimopan, a novel, peripherally acting mu opioid antagonist: results of a multicenter, randomized, double\u2010blind, placebo\u2010controlled, phase III trial of major abdominal surgery and postoperative ileus","volume":"240","author":"Wolff BG","year":"2004","journal-title":"Ann Surg"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01537233"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1999.0029900489"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01561-8"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)80113-5"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(01)00782-6"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010564"},{"key":"e_1_2_1_15_2","first-page":"111","article-title":"Clinical status of methylnaltrexone, a new agent to prevent and manage opioid\u2010induced side effects","volume":"2","author":"Yuan CS","year":"2004","journal-title":"J Support Oncol"},{"key":"e_1_2_1_16_2","unstructured":"MsikaS PeacockJ BadiaX GirodI Baron\u2010PapillonF LoftusJ.The burden of postoperative ileus in four European countries: health authorities and society perspectives. 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