{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:24:18Z","timestamp":1762100658459},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T00:00:00Z","timestamp":1176940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Standard formulation alpha\u2010blocker use has been associated with an increased risk of hypotension\u2010related adverse events, particularly with cardiovascular indications and on treatment initiation. We investigated the association between those fractures that are commonly due to falls and modified\u2010release doxasozin exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2010control study using UK primary care records (the THIN database) showed that 6540 cases aged 50 years or older had a record of first fracture of the hip\/femur, humerus or wrist after May 2001; 26\u2009495 controls had no fracture and were matched on practice, year of birth and sex. Exclusions for the primary analysis were previous benign prostatic hypertrophy (BPH), lower urinary tract symptoms (LUTS) or prostate cancer, major trauma at the time of the case's fracture, or a history of falls. Conditional logistic regression estimated the association between modified\u2010release doxasozin treatment and the occurrence of fractures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No increased risk of fractures was associated with current use of modified\u2010release doxasozin, adjusted odds ratios (ORs) 0.90 (95%CI 0.68, 1.19); previous use, adjusted OR 0.92 (95%CI 0.73, 1.16) or the start of a treatment episode (\u226428 days), crude OR 0.57 (0.17, 1.92). Including those with a history of BPH, LUTS and prostatic carcinoma had little effect, adjusted OR for current use was 0.95 (95%CI 0.74, 1.21). No significant increased risk of fractures was associated with the start of standard preparation alpha\u2010blockers, crude OR 1.42 (95%CI 0.65, 3.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found no association between modified\u2010release doxasozin use and fractured hip\/femur, humerus or wrist in those without a recent history of falls, or trauma. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.1402","type":"journal-article","created":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T11:19:25Z","timestamp":1176981565000},"page":"901-907","source":"Crossref","is-referenced-by-count":14,"title":["Comparative study of modified release alpha\u2010blocker exposure in elderly patients with fractures"],"prefix":"10.1002","volume":"16","author":[{"given":"Gillian C","family":"Hall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex D","family":"McMahon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000052285"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(01)80022-9"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2003.01227.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1999.00067.x"},{"key":"e_1_2_1_6_2","volume-title":"The READ Codes Version 3","author":"NHS Centre for Coding and Classification","year":"1996"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116813"},{"issue":"1","key":"e_1_2_1_8_2","first-page":"s170","article-title":"A study of the incidence of fractures in men receiving medical therapy for lower urinary tract symptoms","volume":"11","author":"Farmer R","year":"2002","journal-title":"PD Safe"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1989.03420180087036"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/17.6.365"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.3.338"},{"key":"e_1_2_1_12_2","first-page":"599","volume-title":"Osteoporosis","author":"Grisso JA","year":"1996"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406023302202"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116314"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.6.587"},{"key":"e_1_2_1_16_2","unstructured":"British National Formulary 48. Joint Formulary Committee British Medical Association Royal Pharmaceutical Society of Great Britain http:\/\/www.bnf.org\/bnf\/bnf\/48\/\/ Date Accessed: January 2005 Access.2004."},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503233321202"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199809243391303"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-139-6-200309160-00010"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01623465"},{"issue":"1","key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/jbmr.5650100115","article-title":"Thiazide diuretics and fractures: can meta\u2010analysis help?","volume":"10","author":"Jones G","year":"1995","journal-title":"J Bone Miner Res"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.14.1567"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200317110-00004"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198702123160702"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7288.704"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/37.1.87"},{"issue":"2","key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1001\/archderm.1996.03890260086013","article-title":"Methotrexate osteopathy in long\u2010term, low\u2010dose methotrexate treatment for psoriasis and rheumatoid arthritis","volume":"132","author":"Zonneveld IM","year":"1996","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.6.993"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.7.983"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7112.841"},{"key":"e_1_2_1_31_2","unstructured":"PRODIGY Guidance\u2014Hypertension. Department of Health http:\/\/www.prodigy.nhs.uk\/hypertension Date Accessed: March 2005 Access.2003."},{"key":"e_1_2_1_32_2","unstructured":"PRODIGY Guidance\u2014Alcohol\u2014problem drinking. Department of Health http:\/\/www.prodigy.nhs.uk\/alcohol_problem_ drinking Date Accessed: March 2005 Access.2000."}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.1402","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.1402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T13:52:30Z","timestamp":1707832350000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.1402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,19]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1002\/pds.1402"],"URL":"https:\/\/doi.org\/10.1002\/pds.1402","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,19]]}}}