{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:01:24Z","timestamp":1790704884184,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,5,8]],"date-time":"2007-05-08T00:00:00Z","timestamp":1178582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of the study was to evaluate the effect of the consumption of anxiolytic or hypnotic drugs on total mortality in a general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We followed a cohort of 7225 men and 7726 women aged 40\u201342 years who underwent health surveys in 1985\u20131989 in two Norwegian counties, with respect to deaths. Mean follow\u2010up period was 18 years. The subjects were categorised according to frequency of anxiolytic or hypnotic drug use during the last month: daily, every week, less than every week and not used during the last month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportion of anxiolytic or hypnotic drug users was 6.6% among men and 16.2% among women. Altogether 402 men and 290 women died. There was an increase in risk of death with an increase in frequency of use. Crude hazard ratios for men and women daily using anxiolytics or hypnotics were 3.1 (95%CI 2.0, 4.8) and 2.7 (1.9, 4.0), respectively, as compared with non\u2010users last month. After adjusting painkiller use and smoking the hazard ratios were lowered, being 2.4 (1.5\u20134.0) (men) and 2.1 (1.4\u20133.2) (women). After additional adjustments for other possible confounders the hazard ratios were further attenuated to 1.5 (0.9\u20132.7) for men and 1.7 (1.1\u20132.6) for women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Daily users of anxiolytic or hypnotic drugs in our study showed higher crude mortality than non\u2010users. However, after adjusting lifestyle and socio\u2010economic variables the difference was markedly reduced suggesting that the remaining excess mortality is due to residual confounding. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.1417","type":"journal-article","created":{"date-parts":[[2007,5,8]],"date-time":"2007-05-08T10:18:48Z","timestamp":1178619528000},"page":"913-918","source":"Crossref","is-referenced-by-count":40,"title":["Use of anxiolytic or hypnotic drugs and total mortality in a general middle\u2010aged population"],"prefix":"10.1002","volume":"16","author":[{"given":"Anne Margrethe","family":"Hausken","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Skurtveit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aage","family":"Tverdal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,8]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"Health Statistics in the Nordic Countries 2001 [Helsestatistik for de nordiske lande 2001].66:2003. 2003. 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