{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:33:11Z","timestamp":1791048791542,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,1,8]],"date-time":"2008-01-08T00:00:00Z","timestamp":1199750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The use of granulocyte colony\u2010stimulating factor (G\u2010CSF) in the treatment of non\u2010chemotherapy drug\u2010 induced agranulocytosis is controversial. We aimed at assessing the effect of G\u2010CSF on the duration of agranulocytosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To assess the effect of G\u2010CSF on the duration of agranulocytosis, a Cox proportional hazard model with an estimated propensity score covariate adjusting for several prognostic factors was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and forty\u2010five episodes of agranulocytosis were prospectively collected from January 1994 to December 2000 in Barcelona (Spain). No differences were found in the case\u2010fatality rate between treated (9 of 101, 8.9%) and not treated (5 of 44, 11.4%) patients. The median time to reach a neutrophil count \u22651.0\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L was 5 days (95%CI 5\u20136) in patients treated with G\u2010CSF compared to 7 days (95%CI 6\u20138) in those not treated, with a hazard ratio of 1.58 (95% CI 1.1\u20132.3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>G\u2010CSF shortens time to recovery in patients with agranulocytosis. However, as an effect on case\u2010fatality has not been recorded, and data on cost\u2010effectiveness are lacking, it would be wise to restrict its use to high\u2010risk patients. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.1542","type":"journal-article","created":{"date-parts":[[2008,1,8]],"date-time":"2008-01-08T10:47:54Z","timestamp":1199789274000},"page":"224-228","source":"Crossref","is-referenced-by-count":19,"title":["Use of granulocyte colony\u2010stimulating factor (G\u2010CSF) and outcome in patients with non\u2010chemotherapy agranulocytosis"],"prefix":"10.1002","volume":"17","author":[{"given":"L.","family":"Ib\u00e1\u00f1ez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sabat\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ballar\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Puig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010R.","family":"Laporte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"and the Agranulocytosis and Aplastic Anaemia Study Group of Barcelona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,2,25]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00012995-200110000-00001"},{"key":"e_1_2_1_3_2","volume-title":"The Drug Etiology of Agranulocytosis and Aplastic Anemia","author":"Kaufman DW","year":"1991"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.8.869"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510360061038"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.2002.00437.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb08042.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2001.00915.x"},{"key":"e_1_2_1_9_2","first-page":"470","article-title":"Prognostic factors of hematologic recovery in non\u2010chemotherapy drug\u2010induced agranulocytosis","volume":"88","author":"Maloisel F","year":"2003","journal-title":"Haematologica"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052706"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.19.4.299.30941"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1999.9.29"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.883"},{"key":"e_1_2_1_14_2","first-page":"2031","article-title":"The application of hematopoietic growth factors in drug\u2010induced agranulocytosis: a review of 70 cases","volume":"8","author":"Sprikkelman A","year":"1994","journal-title":"Leukemia"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0953-6205(02)00085-7"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04017-4"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.1542","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.1542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T13:57:32Z","timestamp":1700056652000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.1542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,25]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1002\/pds.1542"],"URL":"https:\/\/doi.org\/10.1002\/pds.1542","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,25]]}}}