{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:33:10Z","timestamp":1791048790376,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,3,4]],"date-time":"2008-03-04T00:00:00Z","timestamp":1204588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study examined the relationship between antipsychotic medications, categorized by published somnolence effects, and unintentional injury (UI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population included patients of 18\u201364 years of age in a healthcare insurance database with claims from 2001 to 2004 and diagnoses of schizophrenia or affective disorder. A nested case\u2010control design was used with cases defined by an E\u2010code claim (a specified external cause of injury) for selected UIs. For cases, the index date referred to the first injury. For controls, the \u201ccontrol index date\u201d was the date of claim if there was only a single medical claim; for patients with \u22652 claims, one was selected at random as the \u201ccontrol index date.\u201d Both groups had a prescription for a first\u2010generation antipsychotic (FGA) or second\u2010generation antipsychotic (SGA) overlapping the index date. Potential somnolence effects were defined as: low (referent) \u2013 aripiprazole\/ziprasidone; medium \u2013 risperidone; high \u2013 olanzapine\/quetiapine: or any single FGA. Logistic regression models were used to estimate odds ratio (OR) and 95% confidence interval (CI) for UI, adjusted for gender, age, concomitant drug, and psychiatric diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 648 cases and 5214 controls, high\u2010somnolence SGAs were associated with an OR of 1.41 95%CI (1.03\u20131.93) for risk of UI, while medium\u2010somnolence SGAs, and FGAs had ORs of 1.17 95%CI (0.83\u20131.64) and 1.17 95%CI (0.79\u20131.74), respectively. When quetiapine and olanzapine were disaggregated, ORs were 1.61 95%CI (1.15\u20132.25) and 1.25 95%CI (0.89\u20131.74), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High\u2010somnolence SGAs may lead to UI among patients. When prescribing antipsychotics, clinicians should consider potential somnolence. 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