{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:29:24Z","timestamp":1790026164547,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,2,27]],"date-time":"2008-02-27T00:00:00Z","timestamp":1204070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the extent, characteristics and determinants of adverse drug reaction (ADR)\u2010related hospitalisations on a population\u2010based level in 2003.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a cohort study in the Integrated Primary Care Information (IPCI) database, a general practitioners (GPs) research database with longitudinal data from electronic patient records of a group of 150 GP throughout the Netherlands. Hospital discharge letters and patient records were reviewed to evaluate ADR\u2010related hospitalisations applying WHO causality criteria. The prevalence of ADR\u2010related hospitalisations per total admissions and the incidence per drug group were calculated. Avoidability and seriousness of the ADRs causing admission were assessed applying the algorithm from Hallas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 3515 hospital admissions, 1277 elective and 2238 acute. Of the acute admissions, 115 were caused by an ADR giving a prevalence of 5.1% (95% confidence intervals (CI): 4.3\u20136.1%). The prevalence of ADR\u2010related acute admissions increased with age up to 9.8% (95%CI: 7.5\u201312.7) for persons &gt;75 years. The ADRs that most frequently caused hospitalisations were gastro\u2010intestinal bleeding with anti\u2010thrombotics, bradycardia\/hypotension with cardiovascular drugs and neutropenic fever with cytostatics. The incidence rate of ADR\u2010related hospitalisations per drug group was highest for anti\u2010thrombotics and anti\u2010infectives and was relatively low for cardiovascular drugs. Fatality as a direct consequence of the ADR\u2010related admission was 0.31%. In elderly patients 40% of the ADRs causing hospitalisation were judged to be avoidable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The extent and potential avoidability of ADR\u2010related hospitalisations is still substantial, especially in elderly patients. Measures need to be put into place to reduce the burden of ADRs. 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