{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T06:25:20Z","timestamp":1769581520700,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,3,10]],"date-time":"2008-03-10T00:00:00Z","timestamp":1205107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To identify and quantify risk factors associated with preterm birth, stratified by gestational age at birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three case\u2010control analyses were done. Controls were pregnancies of \u226537\u2009weeks of gestational age at birth. Cases were defined as: &lt;28, 28\u201332, 33\u2013\u2009&lt;37\u2009weeks of gestational age at birth respectively in the three case\u2010control analyses. Women were categorized according to whether they carried single or multiple infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Obstetrical conditions (placenta previa, placental abruption), and maternal hypertension were significantly associated with preterm delivery in all case\u2010control analyses (adjusted OR between 1.34\u201319.56, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Leading risk factors for preterm delivery in singleton pregnancies were placental abruption and placenta previa (adjusted ORs 4.85 and 4.13, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). For multiple pregnancies they were polyhydramnios and maternal hypertension (adjusted ORs 4.39 and 2.45, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Obstetrical conditions during the pregnancy and maternal hypertension are important risk factors for preterm birth. 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