{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:54:14Z","timestamp":1789682054001,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,11,4]],"date-time":"2008-11-04T00:00:00Z","timestamp":1225756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To examine what pain and adjuvant medication is prescribed in palliative care patients at home in The Netherlands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a nationwide, representative, prospective study in general practice in The Netherlands, prescribed medication was registered in 95 general practices with a listed population of 374\u2009070 patients. The GPs identified those who received palliative care in a retrospective survey of the 2169 patients who died within the 1\u2010year study period. We analysed the analgesics, laxatives and anti\u2010emetics that were prescribed during the last 3 months of life for these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The response rate of the survey was 74%. 425 patients received palliative care and 73% of them were prescribed pain medication: 55% a non\u2010opioid analgesic (paracetamol, NSAIDs), 21% a weak opioid (tramadol, codeine), and 51% a strong opioid. Relatively more younger than older patients were prescribed strong opioids, and more cancer than non\u2010cancer patients were prescribed an analgesic. During the last 3 months of life, the proportion of patients prescribed a non\u2010opioid or a weak opioid increased gradually. The proportion of patients prescribed a strong opioid increased considerably nearing the patient's death. About one third of the non\u2010cancer patients were prescribed strong opioids, mostly commencing in the last 2 weeks before death. In 48% of all patients with an opioid prescription, the GP did not prescribe a laxative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Weak opioids and laxatives are frequently omitted from pain regimens in palliative care at home in The Netherlands. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.1678","type":"journal-article","created":{"date-parts":[[2008,11,4]],"date-time":"2008-11-04T11:35:28Z","timestamp":1225798528000},"page":"16-23","source":"Crossref","is-referenced-by-count":35,"title":["Prescribing of pain medication in palliative care. 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