{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T08:42:25Z","timestamp":1776588145465,"version":"3.51.2"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,3,12]],"date-time":"2009-03-12T00:00:00Z","timestamp":1236816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Warfarin\u2013drug interactioions, which can result in life\u2010threatening bleeding, are preventable. A 53\u2010year\u2010old man was admitted to hospital with exacerbation of chronic obstructive airways disease, cor pulmonale, pneumonia, deep vein thrombosis and acute pulmonary embolism. His pulmonary thromboemobolism was initially treated by low\u2010molecular\u2010weight\u2010heparin and heparin. After a loading dose of 5\u2009mg for 2 days, warfarin was given in a daily dose of 2\u2009mg. On the fifth day of warfarin therapy, the last dose of Enoxaparin was given in the morning. He had a fall in the bathroom with blunt injury to the right flank. He complained of right thigh numbness and increasing pain and swelling over his right flank and abdomen. A tender mass was noted over the right flank. His Hb level dropped to 9.7\u2009g\/dl. His INR increased from 2.46 to 3.49\u20133.71 one day later. On further questioning, he admitted self applications of 20\u2009g of Analgesic balm (50% methyl salicylate) over his right calf for 3 days. CT scan showed a large right retroperitoneal haematoma and right iliacus intramuscular haematoma. Warfarin was withheld. He was given fresh frozen plasma, packed cells and vitamin K<jats:sub>1<\/jats:sub>. Inferior vena cava filter was inserted. The haematomas were resolving. He was subsequently discharged to convalescence hospital for continuation of anticoagulant therapy and close monitoring. Significant usage of topical methyl salicylate ointment can potentiate the anticoagulant effect of warfarin. The over\u2010anticoagulation and the presence of platelet dysfunction increase the risk of severe bleeding, which can be provoked by trauma. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pds.1729","type":"journal-article","created":{"date-parts":[[2009,3,12]],"date-time":"2009-03-12T08:59:51Z","timestamp":1236848391000},"page":"420-422","source":"Crossref","is-referenced-by-count":7,"title":["Life\u2010threatening retroperitoneal bleeding due to warfarin\u2013drug interactions"],"prefix":"10.1002","volume":"18","author":[{"given":"Thomas Y. K.","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,3,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"403","article-title":"Drug interactions as a cause of overanticoagulation and bleedings in Chinese patients receiving warfarin","volume":"36","author":"Chan TYK","year":"1998","journal-title":"Int J Clin Pharmacol Ther"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1291"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1557(199601)5:1<53::AID-PDS209>3.0.CO;2-G"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/106002809603000903"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(86)90109-X"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/096032719601500905"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.66.775.367"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200730050-00004"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.070946"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.5.1616"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-006-0104-4"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.1.19"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/89.2.127"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2004.02199.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.27.5.675"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.1729","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.1729","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T01:02:19Z","timestamp":1699923739000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.1729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,12]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["10.1002\/pds.1729"],"URL":"https:\/\/doi.org\/10.1002\/pds.1729","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,12]]}}}