{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:46:05Z","timestamp":1759333565061,"version":"3.37.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,5,5]],"date-time":"2009-05-05T00:00:00Z","timestamp":1241481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Drug\u2010induced photosensitivity is difficult to predict and remains a challenge for both the dermatological clinical practice and pharmacovigilance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the association between spectroscopic and molecular characteristics and the occurrence of photosensitivity reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For 143 well\u2010known photosensitisers (e.g. tetracyclines, diuretics), we retrieved information on spectroscopic and molecular parameters, including: absorption maximum<jats:italic>\u03bb<\/jats:italic><jats:sub>max<\/jats:sub>, molar absorption coefficient<jats:italic>\u03b5<\/jats:italic>, area under the absorption curve (AUC), molecular weight and configuration, hetero and aromatic halogen atoms, lipophilicity (log P) and acid\/base status (pKa). In the WHO\u2010ADR database, all reports with suspected adverse drug reactions of the study drugs were selected. We identified all reports on photosensitivity reactions and defined them as cases. All other reports were selected as non\u2010cases. A case\u2013non\u2010case approach was performed to assess the spectroscopic and molecular exposure variables as a factor for photosensitivity reactions. Logistic regression was used to calculate odds ratios (OR) with 95% confidence intervals (CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A<jats:italic>\u03bb<\/jats:italic><jats:sub>max<\/jats:sub>between 290 and 320\u2009nm (OR 3.74, 95% CI 3.45\u20134.06), and an<jats:italic>\u03b5<\/jats:italic>\u2009&gt;\u200920\u2009000\u2009M<jats:sup>\u22121<\/jats:sup>\u2009cm<jats:sup>\u22121<\/jats:sup>(OR 5.49, 95% CI 5.10\u20135.92) were highly associated with the reporting of photosensitivity reactions. Risk of the photosensitivity reactions was significantly increased among intermediate or high AUCs compared to low AUC. Low molecular weight and aromatic halogen atoms were associated with photosensitivity reactions (OR 2.37, 95% CI 2.07\u20132.71 resp. OR 3.37, 95% CI 3.15\u20133.61) as were log<jats:italic>p<\/jats:italic>\u2009&lt;\u20091 and pKa\u2009&lt;\u20097.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The reporting of photosensitivity reactions to established phototoxic drug classes is strongly influenced by spectroscopic and physicochemical characteristics of individual drugs. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.1760","type":"journal-article","created":{"date-parts":[[2009,5,5]],"date-time":"2009-05-05T08:17:30Z","timestamp":1241511450000},"page":"602-609","source":"Crossref","is-referenced-by-count":12,"title":["Risk of drug\u2010induced photosensitivity: focus on spectroscopic and molecular characteristics"],"prefix":"10.1002","volume":"18","author":[{"given":"B.M.","family":"Verdel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.C.","family":"Souverein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.H.B.","family":"Meyboom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.H.","family":"Kardaun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.G.M.","family":"Leufkens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.C.G.","family":"Egberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,5,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200225050-00004"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0031-6997(24)01501-1","article-title":"Cutaneous drug reactions","volume":"53","author":"Svensson CK","year":"2001","journal-title":"Pharmacol Rev"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.18.1993"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190\u20139622(95)91271\u20131"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007.S10227\u2013005\u20130017\u20133"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20130781.2002.02778.x"},{"volume-title":"Side effects in dermatology","year":"2004","author":"Mulder WMC","key":"e_1_2_1_8_2"},{"key":"e_1_2_1_9_2","unstructured":"FDA.Guidance for industry: photosafety testing. 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