{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:24:43Z","timestamp":1778844283795,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T00:00:00Z","timestamp":1260230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"IARC"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the teratogenic effect of very large doses of nitrazepam in children born to pregnant women who attempted suicide and to check the feasibility of self\u2010poisoning pregnant women model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and setting<\/jats:title><jats:p>Comparative analysis of exposed children and their unexposed sibs born to the same mothers who attempted suicide during the study pregnancy and admitted to the toxicological inpatients clinic, Budapest, 1960\u20131993.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study participants<\/jats:title><jats:p>Of 1044 pregnant women who attempted suicide, 107 (10.3%) used large doses of nitrazepam alone or combination with other drugs, and 43 delivered live\u2010born babies, these exposed children were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcomes measures<\/jats:title><jats:p>Structural birth defects, i.e., congenital abnormalities (CAs), pregnancy age at delivery, and birth weight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean dose of nitrazepam used for suicide attempt was 204\u2009mg. Of 43 exposed children, 13 (30.2%) were affected with CAs, while of their 29 sib controls, 3 (10.3%) (OR with 95%CI: 3.8, 1.0\u201314.6). Most CAs in exposed children were mild and belonged to the deformation type. The mean pregnancy age was shorter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The very large doses of nitrazepam used for suicide attempt during pregnancy resulted in a high rate of CAs which may be connected with the disruption of protein metabolism in fetal mesenchyma. The self\u2010poisoning pregnant women model is feasible for the evaluation of teratogenic effect of drugs. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.1885","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T14:40:23Z","timestamp":1260283223000},"page":"175-182","source":"Crossref","is-referenced-by-count":18,"title":["Congenital abnormalities in children of 43 pregnant women who attempted suicide with large doses of nitrazepam"],"prefix":"10.1002","volume":"19","author":[{"given":"J\u00e1nos","family":"Gidai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e1ndor","family":"\u00c1cs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc","family":"B\u00e1nhidy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew E","family":"Czeizel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,12,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0748233708089020"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67600-3"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1996.tb10656.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7374.1207"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30041"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1517\/14740330902916459"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(01)00545-0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(94)90021-3"},{"key":"e_1_2_1_10_2","first-page":"209","article-title":"Pregnancy outcome and health conditions of offspring of self\u2010poisoned pregnant women","volume":"5","author":"Czeizel AE","year":"1984","journal-title":"Acta Paediatr Hung"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00316249"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90548-6"},{"key":"e_1_2_1_13_2","first-page":"347","article-title":"A behavioural teratologic study on offspring of self \u2010poisoned pregnant women","volume":"32","author":"Lendvay A","year":"1992","journal-title":"Acta Paediatr Hung"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00216-0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113749"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.2008.00189.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1032"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1989.tb01365.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0890-6238(94)90029-9"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016348809029859"},{"key":"e_1_2_1_21_2","first-page":"460","volume-title":"USP Dispensing Information, Vol. I. Drug Information for the Health Care Professional, 1996","author":"USP DI","year":"1995"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","unstructured":"KangasL KantoJ ErkkolaR.Transfer of nitrazepam across the human placental Eur J Clin Pharmac.1977;12:355\u2013357.","DOI":"10.1007\/BF00562451"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.306.6876.499"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320040307"},{"key":"e_1_2_1_25_2","first-page":"336","article-title":"Exposure of prescribed drugs in pregnancy and association with congenital malformations","volume":"5","author":"Bracken MB","year":"1981","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198311243092103"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2007.12.003"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2007.12.004"},{"key":"e_1_2_1_29_2","first-page":"59","volume-title":"Res Commun Chemical Pathol Pharmacol","author":"Takeno S","year":"1990"},{"key":"e_1_2_1_30_2","first-page":"437","volume-title":"Res Commun Chemical Pathol Pharmacol","author":"Saito H","year":"1984"},{"key":"e_1_2_1_31_2","first-page":"179","article-title":"Smoking and alcohol drinking during pregnancy: the validity of retrospective maternal self\u2010reported information","volume":"12","author":"Czeizel AE","year":"2004","journal-title":"Centr Eur J Publ Health"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.1885","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.1885","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.1885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T15:20:28Z","timestamp":1700580028000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.1885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,8]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["10.1002\/pds.1885"],"URL":"https:\/\/doi.org\/10.1002\/pds.1885","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,8]]}}}