{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:42:38Z","timestamp":1788871358646,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,2,24]],"date-time":"2010-02-24T00:00:00Z","timestamp":1266969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Medical Products Agency"},{"DOI":"10.13039\/501100004348","name":"Stockholm County Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Federation of County Councils"},{"name":"Drug Committees of Stockholm"},{"name":"Physicians Against AIDS Research Foundation"},{"DOI":"10.13039\/100001808","name":"National Institute of Public Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001808","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swedish Institute for Infectious Disease Control and the Karolinska University hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine if anti\u2010retroviral therapy (ART) in HIV\u2010infected patients is associated with an increased risk for development of abdominal wall hernia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cohort study of 1072 HIV\u2010infected patients in Sweden. Information was collected by questionnaires to patients and treating physicians, chart reviews by study physicians and regular blood tests for metabolic disorders. Adjusted relative risks were estimated by Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty\u2010three patients (5.9%) developed abdominal wall hernia during the study period, 34 inguinal and 29 midline. Compared to the male general population, inguinal hernia was twice as common in the male study population, standardized incidence ratio (SIR) 2.0 (95% confidence interval (CI) 1.4\u20132.8). An increased incidence rate of abdominal wall hernia was found in patients exposed to ART, 11.3 per 1000 person\u2010years (PY) compared with therapy na\u00efves, 2.1 per 1000 PY. When adjusting for confounding risk\u2010factors, ART containing protease inhibitors (PIs) during the 2nd and 3rd year of treatment was associated with the development of midline hernia with a hazard ratio (HR) of 10.7 (95%CI 1.3\u201385.7), and of inguinal hernia with an HR of 4.4 (95%CI 1.1\u201316.6). Other independent risk factors were age and diabetes\/impaired fasting glucose for midline hernia, and age and a previous diagnosis of AIDS for inguinal hernia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found an increased risk of developing abdominal wall hernia associated with PI\u2010containing ART. The size of the study\u2010population did not permit any conclusions regarding non\u2010PI\u2010containing ART. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.1922","type":"journal-article","created":{"date-parts":[[2010,2,24]],"date-time":"2010-02-24T06:12:19Z","timestamp":1266991939000},"page":"465-473","source":"Crossref","is-referenced-by-count":6,"title":["Increased risk of abdominal wall hernia associated with combination anti\u2010retroviral therapy in HIV\u2010infected patients\u2014results from a Swedish cohort\u2010study"],"prefix":"10.1002","volume":"19","author":[{"given":"Anders","family":"Sundstr\u00f6m","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6rjan","family":"Mortimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00f6rje","family":"\u00c5kerlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Flamholc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"H\u00e5kang\u00e5rd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Granholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingemar","family":"Persson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Morfeldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,24]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199807000-00003"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1097\/00002030-199909100-00009","article-title":"A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long\u2010term nucleoside analogue therapy","volume":"13","author":"Saint\u2010Marc T","year":"1999","journal-title":"AIDS"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08468-2"},{"issue":"9256","key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S0140-6736(00)04056-3","article-title":"Risk of lipodystrophy in HIV\u20101 infected patients treated with protease inhibitors: a prospective cohort study","volume":"357","author":"Martinez E","year":"2001","journal-title":"Lancet"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200002180-00001"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199814000-00004"},{"key":"e_1_2_1_8_2","unstructured":"National Quality Registry for Hernia Surgery.https:\/\/sbr.norrnod.se\/html\/fakta.stm[Accessed on 23 March2006]."},{"key":"e_1_2_1_9_2","unstructured":"Centre of Epidemiology National Board of Health and Welfare.http:\/\/www.sos.se\/epc\/epceng.htm[Accessed on 23 March2006]."},{"key":"e_1_2_1_10_2","unstructured":"Yearly Report 2004. National Quality Registry for Hernia.https:\/\/sbr.norrnod.se\/html\/dl\/pub\/red04.pdf[Accessed on 24 March2006]."},{"key":"e_1_2_1_11_2","unstructured":"Personal Communication: Dr P\u00e4r Nordin and Dr Erik Nilsson of the National Quality Registry of Inguinal Hernia Sweden March2006."},{"key":"e_1_2_1_12_2","unstructured":"The Tierp Research Database.http:\/\/www.pubcare.uu.se\/epidemiologi\/[Accessed on 24 March2006]."},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.4.2.201"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(05)70364-9"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2005.00264.x"},{"key":"e_1_2_1_16_2","first-page":"1585","volume-title":"Principles of Surgery","author":"Wantz GE","year":"1999"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-001-0238-6"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.1922","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.1922","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.1922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T10:23:21Z","timestamp":1700562201000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.1922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,24]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.1002\/pds.1922"],"URL":"https:\/\/doi.org\/10.1002\/pds.1922","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,24]]}}}