{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T13:47:11Z","timestamp":1778593631051,"version":"3.51.4"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,3,22]],"date-time":"2010-03-22T00:00:00Z","timestamp":1269216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>When a biological hypothesis of causal effect can be inferred, the hypothesis can sometimes be tested in the selfsame database that gave rise to the study data from which the hypothesis grew. Valid testing happens when the inferred biological hypothesis has scientific implications that predict new relations between observations already recorded. Testing for the existence of the new relations is a valid assessment of the biological hypothesis, so long as the newly predicted relations are not a logical correlate of the observations that stimulated the hypothesis in the first place. These predictions that lead to valid tests might be called \u2018orthogonal\u2019 predictions in the data, and stand in marked contrast to \u2018scrawny\u2019 hypotheses with no biological content, which predict simply that the same data relations will be seen in a new database. The Universal Data Warehouse will shortly render moot searches for new databases in which to test. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pds.1929","type":"journal-article","created":{"date-parts":[[2010,3,22]],"date-time":"2010-03-22T11:35:10Z","timestamp":1269257710000},"page":"529-532","source":"Crossref","is-referenced-by-count":19,"title":["Orthogonal predictions: follow\u2010up questions for suggestive data"],"prefix":"10.1002","volume":"19","author":[{"given":"Alexander M.","family":"Walker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,3,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00237-7"},{"issue":"34","key":"e_1_2_1_3_2","first-page":"786","article-title":"Suspension of rotavirus vaccine after reports of intussusception\u2014United States, 1999","volume":"53","author":"Centers for Disease Control and Prevention (CDC)","year":"2004","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_1_4_2","unstructured":"World Health Organization.Report of the Meeting on Future Directions for Rotavirus Vaccine Research in Developing Countries Geneva 9\u201311 February 2000 Geneva (Publication WHO\/V&B\/00.23)."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1020-49892000001000002"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.2307\/2686093"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102223440804"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1130\/G21136.1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199305000-00012"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-86650-0"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.1929","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.1929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T15:23:54Z","timestamp":1700580234000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.1929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,22]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.1002\/pds.1929"],"URL":"https:\/\/doi.org\/10.1002\/pds.1929","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,22]]}}}