{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T14:03:30Z","timestamp":1777989810304,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,8,27]],"date-time":"2011-08-27T00:00:00Z","timestamp":1314403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To validate, using physician review of abstracted medical chart data as a gold standard, a claims\u2010based algorithm developed to identify gastrointestinal (GI) perforation cases among rheumatoid arthritis (RA) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with established RA, aged 18\u2009years or older with hospital admissions between January 2004 and September 2009, were selected from a large US\u2010hospital\u2010based database. An algorithm with International Classification of Diseases, Ninth Revision, Clinical Modification (ICD\u20109\u2010CM) diagnosis codes for GI perforation and combinations of GI\u2010related diagnosis codes and Current Procedural Terminology (CPT\u20104) procedure codes for relevant GI surgeries was used to identify potential GI perforation cases. Two senior experienced specialist physicians independently reviewed abstracted chart data and classified cases as confirmed or unconfirmed GI perforations. Positive predictive values (PPVs) to identify confirmed GI perforation were calculated and stratified by upper versus lower GI tract.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 86 of 92 GI perforation cases were confirmed, yielding an overall PPV of 94% (95%confidence interval [CI]\u2009=\u200986%\u201398%). PPV was 100% (95%CI\u2009=\u2009100%\u2013100%) for upper GI perforation (esophagus, stomach) and 91% (95%CI\u2009=\u200990%\u201397%) for lower GI perforation (small intestine, PPV\u2009=\u2009100%; large intestine, PPV\u2009=\u200994%; unspecified lower GI, PPV\u2009=\u200989%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This algorithm, consisting of a combination of ICD\u20109\u2010CM diagnosis and CPT\u20104 codes, could be used in future safety studies to evaluate GI perforation risk factors in RA patients. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.2215","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T03:51:30Z","timestamp":1314849090000},"page":"1150-1158","source":"Crossref","is-referenced-by-count":20,"title":["Validation of ICD\u20109\u2010CM codes to identify gastrointestinal perforation events in administrative claims data among hospitalized rheumatoid arthritis patients"],"prefix":"10.1002","volume":"20","author":[{"given":"Jeffrey R.","family":"Curtis","sequence":"first","affiliation":[{"name":"UAB University of Alabama  Birmingham AL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih\u2010Yin","family":"Chen","sequence":"additional","affiliation":[{"name":"United BioSource Corporation  Lexington MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winifred","family":"Werther","sequence":"additional","affiliation":[{"name":"Genentech  South San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ani","family":"John","sequence":"additional","affiliation":[{"name":"Genentech  South San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Eastern Virginia Medical School  Norfolk VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,27]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Gastrointestinal perforation.MedlinePlus Medical Encyclopedia. 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