{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:33:35Z","timestamp":1761975215616,"version":"3.37.3"},"reference-count":3,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T00:00:00Z","timestamp":1315872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"crossref","award":["R01 HD046595-04"],"award-info":[{"award-number":["R01 HD046595-04"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Asisa"},{"name":"National University of Singapore-Overseas Postdoctoral Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Imperfect recall of exposure timing challenges the ascertainment of medications in interview\u2010based studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We propose an algorithm to classify medication exposure, taking into account recall certainty. The availability of medication use details, including duration of use, start and stop dates, and maternal estimates of how certain they were about these dates, allowed classification of subjects as either likely or possibly exposed in the first trimester of pregnancy. We applied the algorithm to study an association between prenatal tetracycline exposure and risk of congenital heart defects previously reported by the National Birth Defects Prevention Study, using 1993\u20132008 data from 11\u2009517 subjects in the Slone Epidemiology Center Birth Defects Study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among women exposed to tetracyclines during pregnancy (<jats:italic>n<\/jats:italic>\u2009=\u200958), 50% and 19% were likely and possibly exposed, respectively, in the first trimester, and 31% were exposed outside the first trimester. Compared with non\u2010use during pregnancy, the crude OR for exposure outside the first trimester was 1.0 (95%CI 0.4\u20132.5), and that for exposed (likely or possibly, combined) in the first trimester was 1.7 (95%CI 0.9\u20133.2); however, the ORs based on the algorithms were 0.9 (95%CI 0.3\u20133.0) for possibly exposed and 2.2 (95%CI 1.0\u20134.6) for likely exposed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A \u201ccertainty\u2010response\u201d (stronger association with higher level of certainty) was found within exposures in the window of etiological interest. Algorithms for exposure classification that incorporate recall certainty may be useful in interview\u2010based studies. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.2234","type":"journal-article","created":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T08:23:44Z","timestamp":1315902224000},"page":"1210-1216","source":"Crossref","is-referenced-by-count":8,"title":["Drug certainty\u2010response in interview\u2010based studies"],"prefix":"10.1002","volume":"20","author":[{"given":"Wai\u2010Ping","family":"Yau","sequence":"first","affiliation":[{"name":"Department of Epidemiology Harvard School of Public Health  Boston MA USA"},{"name":"Department of Pharmacy, Faculty of Science National University of Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kueiyu Joshua","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard School of Public Health  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha M.","family":"Werler","sequence":"additional","affiliation":[{"name":"Slone Epidemiology Center Boston University  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Louik","sequence":"additional","affiliation":[{"name":"Slone Epidemiology Center Boston University  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen A.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Slone Epidemiology Center Boston University  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Hern\u00e1ndez\u2010D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard School of Public Health  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,13]]},"reference":[{"volume-title":"Modern Epidemiology","year":"2008","author":"Rothman KJ","key":"e_1_2_7_2_1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2009.188"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114286"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.2234","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.2234","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.2234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:20:01Z","timestamp":1695511201000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.2234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,13]]},"references-count":3,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1002\/pds.2234"],"URL":"https:\/\/doi.org\/10.1002\/pds.2234","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"type":"print","value":"1053-8569"},{"type":"electronic","value":"1099-1557"}],"subject":[],"published":{"date-parts":[[2011,9,13]]}}}