{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T13:37:09Z","timestamp":1759412229447},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,11,3]],"date-time":"2011-11-03T00:00:00Z","timestamp":1320278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Background rates for common health problems have seldom been estimated to facilitate interpretation of signals that may occur after a new public health intervention. Background rates of diagnoses from general practitioners (GPs) and gynecologists (GYNs) were assessed before the implementation of human papillomavirus (HPV) immunization program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study used data collected in 2006 in France. All visits of women (aged 11\u201323\u2009years) to a GP or a GYN participating in the longitudinal patient data (LPD) network were considered. Diagnoses and symptoms were retrieved and classified according to the International Classification of Primary Care. Only diagnoses made in \u22651% of visits were reported in primary analyses. Independent analyses were performed for visits to GPs and GYNs and for adolescents and young adults. Finally, the rates of pre\u2010specified health problems of interest (e.g., because of their potential identification as signals after HPV immunization) were computed from processed diagnostic data, using time windows consistent with HPV vaccination scheme.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>About 380\u2009813 GP and 36\u2009329 GYN visits were analyzed. Acute upper respiratory infections were the most frequently recorded diagnoses by GPs, accounting for 11\u2009783 per 100\u2009000 visits per year. Visits related to the respiratory system accounted for 10 of the 23 most frequent diagnoses by GPs. Genital candidiasis was the most frequent GYN diagnosis, accounting for 4746 per 100\u2009000 visits per year. Most GYN visits were for pregnancy\u2010related issues or menstrual problems. The main diagnoses were similar in adolescents compared with young adults in both GP and GYN settings. Pre\u2010specified health problems occurred at high rates, as exemplified by acne that was diagnosed in 0.8% of patients during time windows consistent with HPV immunization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Diagnostic data processed from electronic health records identified the rates of common health events experienced by young female patients routinely visiting their GP or GYN before HPV immunization. Such rates may prove useful in interpreting adverse events reported after the launch of new medical interventions. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.2243","type":"journal-article","created":{"date-parts":[[2011,11,4]],"date-time":"2011-11-04T04:02:24Z","timestamp":1320379344000},"page":"261-268","source":"Crossref","is-referenced-by-count":5,"title":["Health problems most commonly diagnosed among young female patients during visits to general practitioners and gynecologists in France before the initiation of the human papillomavirus vaccination program"],"prefix":"10.1002","volume":"21","author":[{"given":"Eric Van","family":"Ganse","sequence":"first","affiliation":[{"name":"Pharmacoepidemiology CHU\u2010Lyon  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Letrilliart","sequence":"additional","affiliation":[{"name":"Department of General Practice Claude\u2010Bernard University  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Borne","sequence":"additional","affiliation":[{"name":"Gynecologist  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Morand","sequence":"additional","affiliation":[{"name":"CSD  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthieu","family":"Robain","sequence":"additional","affiliation":[{"name":"CSD  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire Anne","family":"Siegrist","sequence":"additional","affiliation":[{"name":"Center for Vaccinology and Neonatal Immunology, Medical Faculty University of Geneva  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,3]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"Centers for Disease Control and Prevention (CDC); Advisory Committee on Immunization Practices (ACIP). Quadrivalent Human Papillomavirus Vaccine: Recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"56","author":"Markowitz LE","year":"2007","journal-title":"MMWR Recomm Rep."},{"key":"e_1_2_7_3_1","unstructured":"AFSSAPS (French Drug Agency).Risk Management Programme of Gardasil (in French). Atwww.afssaps.fr. Accessed on March 31 2011"},{"key":"e_1_2_7_4_1","unstructured":"AFSSAPS (French Drug Agency).Gardasil: first assessment of risk surveillance in France. July 2008. Atwww.afssaps.fr. Accessed on March 31 2011"},{"key":"e_1_2_7_5_1","unstructured":"AFSSAPS (French Drug Agency).Gardasil: second assessment of European and French Risk Management Programme. September 2009. Atwww.afssaps.fr. Accessed on March 31 2011."},{"key":"e_1_2_7_6_1","first-page":"72","article-title":"HPV vaccination catch up program \u2013 utilization by young Australian women","volume":"38","author":"Weisberg E","year":"2009","journal-title":"Aust Fam Physicians"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318149dfea"},{"key":"e_1_2_7_8_1","first-page":"139","article-title":"vaccination reactions\u2010\u2010more hype than harm","volume":"38","author":"Douglas RJ","year":"2009","journal-title":"Aust Fam Physician"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1201"},{"key":"e_1_2_7_10_1","article-title":"Vaccin anti\u2010HPV et cancer du col ut\u00e9rin [Review. HPV vaccine and uterus cancer]","volume":"459","author":"Collectif","year":"2007","journal-title":"Bibliomed"},{"key":"e_1_2_7_11_1","article-title":"Vaccin anti\u2010papillomavirus\u2009: balance b\u00e9n\u00e9fices\/risques. [Review. HPV vaccine\u2009: benefit\u2010risk assessment]","volume":"560","author":"Collectif","year":"2009","journal-title":"Bibliomed"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200629070-00002"},{"key":"e_1_2_7_13_1","first-page":"31","article-title":"The probability of specific diagnoses for patients presenting with common symptoms to Dutch family physicians","volume":"51","author":"Okkes I","year":"2002","journal-title":"J Fam Pract"},{"key":"e_1_2_7_14_1","first-page":"809","article-title":"The International Classification of Primary Care (ICPC\u20102): an essential tool in the EPR of the GP","volume":"124","author":"Verbeke M","year":"2006","journal-title":"Stud Health Technol Inform."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1557(199709\/10)6:5<325::AID-PDS283>3.0.CO;2-B"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61877-8"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.02.106"},{"key":"e_1_2_7_18_1","first-page":"1","article-title":"Introducing Gate Keeping in France: first assessment of the preferred doctor scheme reform","volume":"124","author":"Dourgnon P","year":"2007","journal-title":"QES"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp0905338"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.2243","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.2243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.2243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T03:26:32Z","timestamp":1697513192000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.2243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1002\/pds.2243"],"URL":"https:\/\/doi.org\/10.1002\/pds.2243","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,3]]}}}