{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T06:56:34Z","timestamp":1778309794533,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T00:00:00Z","timestamp":1328140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Claims databases are an important source for pharmacoepidemiological studies although they often lack information on some confounders. Two\u2010phase methodology was used to estimate the bleeding risk in patients treated with phenprocoumon from claims data combined with additional information on body mass index (BMI) and smoking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a nested case\u2013control study using claims data from 2004 to 2007 (phase 1). Additional information was obtained from interviews in a subset of 505 insurants (phase 2). Adjusted bleeding OR were calculated using logistic regression using data from the complete case\u2013control dataset. Furthermore, a two\u2010phase analysis was conducted, taking into consideration phase 2 data on BMI and smoking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The phase 1 sample included 1248 cases and 24\u2009960 controls. In phase 1, we observed an adjusted bleeding ORs of 3.93 (95%CI: 2.75\u20135.61) for male subjects aged 55 years taking phenprocoumon. The bleeding risk associated with phenprocoumon use decreased with increasing age. The two\u2010phase analysis revealed smoking and a high BMI as risk factors for bleeding. The OR for phenprocoumon obtained from the two\u2010phase analysis was of similar size as the phase 1 estimate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Phase 2 data added valuable information on smoking and BMI. However, phase 1 results did not change dramatically after accounting for phase 2 information, which is reassuring for the validity of database studies. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.3193","type":"journal-article","created":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T14:29:52Z","timestamp":1328192992000},"page":"535-545","source":"Crossref","is-referenced-by-count":11,"title":["Does additional confounder information alter the estimated risk of bleeding associated with phenprocoumon use\u2014results of a two\u2010phase study"],"prefix":"10.1002","volume":"21","author":[{"given":"Sigrid","family":"Behr","sequence":"first","affiliation":[{"name":"Bremen Institute for Prevention Research and Social Medicine Bremen University  Bremen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Schill","sequence":"additional","affiliation":[{"name":"Bremen Institute for Prevention Research and Social Medicine Bremen University  Bremen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Pigeot","sequence":"additional","affiliation":[{"name":"Bremen Institute for Prevention Research and Social Medicine Bremen University  Bremen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1973"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529883"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113266"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199805000-00016"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1119"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/75.1.11"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115074"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780100509"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20100258(19970130)16:2\u2009<\u2009117::AID\u2010SIM475\u2009>\u20093.0.CO;2\u20135"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v043.i11"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467\u2010968.00078"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2007.08.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000080678.09344.8D"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.3_suppl.287S"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.5.1390"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.09.025"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.22.2557"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.2002.1008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000065200.93070.32"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000100165.36466.95"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895\u20104356(01)00485\u20101"},{"key":"e_1_2_8_23_1","unstructured":"Meda Pharma.Fachinformation Marcumar.http:\/\/www pharmnet\u2010bund de\/dynamic\/de\/index html2009; (accessed 18 December 2009)"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-141-10-200411160-00005"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.3193","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.3193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T14:38:39Z","timestamp":1697294319000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.3193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,2]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1002\/pds.3193"],"URL":"https:\/\/doi.org\/10.1002\/pds.3193","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,2]]}}}