{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:18:03Z","timestamp":1791310683065,"version":"4.3.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T00:00:00Z","timestamp":1328745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To estimate the number of deaths from valvular insufficiency caused by the use of the fenfluramine\u2010derivative benfluorex during the period 1976\u20132009 in France.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our calculation was based on (i) the exposure level to benfluorex in the French population, derived from sales figures for the period 1976\u20132009 and from the main characteristics of benfluorex use provided by the French health products safety agency; (ii) the relative risk of hospitalization for valvular insufficiency among exposed compared with unexposed individuals with diabetes, originating from a cohort study based on a French medico\u2010administrative database, with benfluorex exposure assessed in 2006; (iii) the incidence of hospitalization for valvular insufficiency among exposed individuals, originating from the same database; and (iv) the mortality associated with valvular heart disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In France, use of benfluorex during the period 1976\u20132009 is likely to be responsible for around 3100 hospitalizations and 1300 deaths due to valvular insufficiency. These figures may be underestimations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The grave consequences benfluorex use have had for many people lend support to the public investigation, which has been set to understand the reasons that have contributed to the delay in withdrawing benfluorex from the French market. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.3213","type":"journal-article","created":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T11:13:30Z","timestamp":1328786010000},"page":"343-351","source":"Crossref","is-referenced-by-count":48,"title":["Estimate of deaths due to valvular insufficiency attributable to the use of benfluorex in France"],"prefix":"10.1002","volume":"21","author":[{"given":"Agn\u00e8s","family":"Fournier","sequence":"first","affiliation":[{"name":"INSERM CESP Centre for Research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health Team  Villejuif France"},{"name":"Paris South University UMRS 1018  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Zureik","sequence":"additional","affiliation":[{"name":"INSERM, U700  Paris France"},{"name":"Paris University VII, UMRS 700  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,9]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"59","article-title":"Tolerance and cross tolerance to the anorexigenic effect of appetite suppressants in rats","volume":"2","author":"Opitz K","year":"1978","journal-title":"Int J Obes"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1660639"},{"key":"e_1_2_7_4_1","unstructured":"LechatP Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire des Produits de Sant\u00e9.Propri\u00e9t\u00e9s pharmacologiques du benfluorex; November2010.http:\/\/www.afssaps.fr\/content\/download\/29421\/387796\/version\/4\/file\/Benfluorex_Donnees\u2010pharmacologiques.pdf(accessed 22 September 2011)."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199608293350901"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199712113372414"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp068265"},{"key":"e_1_2_7_8_1","unstructured":"Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire des Produits de Sant\u00e9.Suspension d'autorisation de mise sur le march\u00e9 des m\u00e9dicaments contenant du benfluorex \u2013 communiqu\u00e9; November2009.http:\/\/www.afssaps.fr\/Infos\u2010de\u2010securite\/Communiques\u2010Points\u2010presse\/Suspension\u2010d\u2010autorisation\u2010de\u2010mise\u2010sur\u2010le\u2010marche\u2010des\u2010medicaments\u2010contenant\u2010du\u2010benfluorex\u2010communique(accessed 22 September 2011)."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472\u20108206.2006.00441.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00086308"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jeq172"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2009.09.015"},{"key":"e_1_2_7_13_1","unstructured":"Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire des Produits de Sant\u00e9.Commission nationale de pharmacovigilance. 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