{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:12:56Z","timestamp":1759482776816},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,17]],"date-time":"2012-02-17T00:00:00Z","timestamp":1329436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Nonsteroidal anti\u2010inflammatory drugs (NSAIDs) may be associated with severe renal complications, including acute renal failure, reduced glomerular filtration rate and interstitial nephritis. Caution against NSAIDs is therefore recommended in advanced chronic kidney disease. In this study, we examined NSAID use, aetiology and comorbidity among a national cohort of patients before the initiation of chronic renal replacement therapy (RRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients initiated on chronic RRT in the period 1997\u20132006 were identified in the Danish National Registry on Regular Dialysis and Transplantation, including etiological diagnosis. The use of NSAID before the start of RRT was studied by linkage to the National Prescription Register and comorbidity by linkage to the National Patient Registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 6663 patients were included in the study, and 2407 patients (36.1%) were prescribed NSAID in the 3\u2009years before the start of RRT. These patients were older (mean age = 63.0 vs 61.4\u2009years) and had a significantly higher degree of comorbidity (Charlson score = 2.85 vs 2.61, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) compared with patients not treated with NSAIDs. In the 3\u2009years leading up to RRT, the number of patients treated with NSAID each year and the cumulated median length of treatment including all NSAIDs were stable at approximately 20% and 40\u2009days, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study of a nationwide group of patients, we observed a widespread use of NSAID with an unaffected high annual incidence in the 3\u2009years leading up to the initiation of RRT. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.3227","type":"journal-article","created":{"date-parts":[[2012,2,17]],"date-time":"2012-02-17T05:20:29Z","timestamp":1329456029000},"page":"428-434","source":"Crossref","is-referenced-by-count":15,"title":["Use of nonsteroidal anti\u2010inflammatory drugs prior to chronic renal replacement therapy initiation: a nationwide study"],"prefix":"10.1002","volume":"21","author":[{"given":"S\u00f8ren Lund","family":"Kristensen","sequence":"first","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital  Gentofte Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emil L.","family":"Fosb\u00f8l","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital  Gentofte Hellerup Denmark"},{"name":"Duke Medical Center Duke Clinical Research Institute  Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Lise","family":"Kamper","sequence":"additional","affiliation":[{"name":"Department of Nephrology Copenhagen University Hospital  Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital  Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine","family":"Hommel","sequence":"additional","affiliation":[{"name":"Department of Nephrology Copenhagen University Hospital  Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Lamberts","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital  Gentofte Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steen Z.","family":"Abildstr\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital  Bispebjerg Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thalia M.","family":"Blicher","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital  Bispebjerg Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Torp\u2010Pedersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital  Gentofte Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar H.","family":"Gislason","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital  Gentofte Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,17]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"18","article-title":"Epidemiology of NSAID induced gastrointestinal complications","volume":"56","author":"Singh G","year":"1999","journal-title":"J Rheumatol Suppl"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1592"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.181424"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/039139880703001203"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.69.Suppl_1.SI53"},{"key":"e_1_2_8_7_1","first-page":"462","article-title":"Acute effects of captopril and ibuprofen on proteinuria in patients with nephrosis","volume":"116","author":"Allon M","year":"1990","journal-title":"J Lab Clin Med"},{"key":"e_1_2_8_8_1","first-page":"F233","article-title":"Interaction of captopril and ibuprofen on glomerular and tubular function in humans","volume":"259","author":"Allon M","year":"1990","journal-title":"Am J Physiol"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000168201"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.204"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2008.525"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.02.015"},{"key":"e_1_2_8_13_1","unstructured":"Nephrology DSo.Danish Registry of Nephrology.www.nephrology.dk 2011."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp571"},{"key":"e_1_2_8_15_1","first-page":"445","article-title":"The Danish prescription registries","volume":"44","author":"Gaist D","year":"1997","journal-title":"Dan Med Bull"},{"key":"e_1_2_8_16_1","first-page":"263","article-title":"The Danish National Hospital Register. 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