{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:31:35Z","timestamp":1791297095859,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T00:00:00Z","timestamp":1331856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hartford Geriatrics Health Outcomes Research Scholars Award","award":["K23 AG033204"],"award-info":[{"award-number":["K23 AG033204"]}]},{"name":"Hartford Geriatrics Health Outcomes Research Scholars Award","award":["T32-HL098048"],"award-info":[{"award-number":["T32-HL098048"]}]},{"name":"Men's Associates of Hebrew SeniorLife"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Although chronic use of diuretics has been implicated as a risk factor for falls, it is unknown whether changes in diuretic drugs are associated with an acutely elevated risk of falls. We evaluated the relationship between change in a diuretic prescription (new prescription or increased dose) and the occurrence of documented falls among nursing home residents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants of the cohort were 1785 long\u2010term care residents of two large nursing homes (2005\u20132010; Boston, MA). A self\u2010matched, case\u2010crossover analysis was used to examine whether there is an acutely increased risk of falling in the day following a diuretic drug change compared with days without a diuretic drug change. Odds ratios with 95% confidence intervals were calculated using conditional logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a mean follow\u2010up of 8.4\u2009months, 1181 participants experienced an incident fall. Nine participants experienced a diuretic change on the day before the fall. The odds of falling one day following a change in a diuretic was elevated (OR\u2009=\u20092.08; 95%CI\u2009=\u20090.89, 4.86). The association was stronger and reached nominal statistical significance when loop diuretics were examined separately (OR\u2009=\u20092.46; 95%CI\u2009=\u20091.02, 5.92). We estimated that, for every 271 loop diuretic drug changes, one excess fall occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nursing home residents are at an increased risk of falls in the day following a new prescription or increased dose of a loop diuretic drug. Extra precautions should be taken immediately following a loop diuretic drug change in an effort to prevent falls. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.3256","type":"journal-article","created":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T04:24:57Z","timestamp":1331871897000},"page":"560-563","source":"Crossref","is-referenced-by-count":42,"title":["New loop diuretic prescriptions may be an acute risk factor for falls in the nursing home"],"prefix":"10.1002","volume":"21","author":[{"given":"Sarah D.","family":"Berry","sequence":"first","affiliation":[{"name":"Hebrew SeniorLife Institute for Aging Research and Beth Israel Deaconess Medical Center Division of Gerontology  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray A.","family":"Mittleman","sequence":"additional","affiliation":[{"name":"Department of Medicine Beth Israel Deaconess Medical Center Cardiovascular Epidemiology Research Unit  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Research and Training Unit Boston University School of Medicine  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Department of Medicine Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis A.","family":"Lipsitz","sequence":"additional","affiliation":[{"name":"Hebrew SeniorLife Institute for Aging Research and Beth Israel Deaconess Medical Center Division of Gerontology  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Mostofsky","sequence":"additional","affiliation":[{"name":"Department of Medicine Beth Israel Deaconess Medical Center Cardiovascular Epidemiology Research Unit  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Goldense","sequence":"additional","affiliation":[{"name":"Hebrew SeniorLife Institute for Aging Research and Beth Israel Deaconess Medical Center Division of Gerontology  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas P.","family":"Kiel","sequence":"additional","affiliation":[{"name":"Hebrew SeniorLife Institute for Aging Research and Beth Israel Deaconess Medical Center Division of Gerontology  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.357"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-6-199409150-00009"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr113"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115853"},{"key":"e_1_2_7_6_1","unstructured":"Pharmacists ASoH\u2010S.American Hospital Formulary Service.http:\/\/www.ahfsdruginformation.com\/. 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Accessed August 21 2011."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/14034948020300011201"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2003.51053.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.8.5.438"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2176"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.3256","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.3256","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.3256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T14:38:26Z","timestamp":1697294306000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.3256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,16]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1002\/pds.3256"],"URL":"https:\/\/doi.org\/10.1002\/pds.3256","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,16]]}}}