{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:02:27Z","timestamp":1780081347225,"version":"3.54.0"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,9,2]],"date-time":"2012-09-02T00:00:00Z","timestamp":1346544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Thioridazine is a first\u2010generation antipsychotic drug that was withdrawn from the market worldwide in 2005. The outcome of clinically stable schizophrenia patients who used thioridazine before market withdrawal was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nationwide registers in Finland were utilized to study thioridazine use, hospitalization rate and length of hospital stay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although thioridazine use continued to diminish year after year, the hospitalization rate remained constant until the withdrawal year of 2005, when the percentage of patients hospitalized for schizophrenia doubled.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The market withdrawal of thioridazine predisposed many stable patients towards psychotic relapses. In order to minimize this kind of risk, an overall risk\u2013benefit assessment and a clear\u2010cut plan for the replacement of an antipsychotic should be established before market withdrawal. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.3346","type":"journal-article","created":{"date-parts":[[2012,9,2]],"date-time":"2012-09-02T23:35:10Z","timestamp":1346628910000},"page":"1227-1231","source":"Crossref","is-referenced-by-count":32,"title":["Outcome of patients after market withdrawal of thioridazine: A retrospective analysis in a nationwide cohort"],"prefix":"10.1002","volume":"21","author":[{"given":"Maija","family":"Purhonen","sequence":"first","affiliation":[{"name":"Department of Psychiatry Kuopio University Hospital  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu","family":"Koponen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Kuopio University Hospital  Kuopio Finland"},{"name":"Department of Psychiatry, Institute of Clinical Medicine University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Tiihonen","sequence":"additional","affiliation":[{"name":"Karolinska institutet Department of Clinical Neuroscience  Stockholm Sweden"},{"name":"University of Eastern Finland Department of Forensic Psychiatry, Niuvanniemi Hospital  Kuopio Finland"},{"name":"National Institute for Health and Welfare  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Tanskanen","sequence":"additional","affiliation":[{"name":"Karolinska institutet Department of Clinical Neuroscience  Stockholm Sweden"},{"name":"National Institute for Health and Welfare  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(69)90271-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02035-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.180.6.515"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1176\/appi.ajp.158.11.1774","article-title":"Antipsychotic drugs: Prolonged QTc interval, torsade de pointes, and sudden death","volume":"158","author":"Glassmann AH","year":"2001","journal-title":"Am J Psychiatry"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.yic.0000166405.49473.70"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7352.1519"},{"key":"e_1_2_6_8_1","first-page":"183","article-title":"Repercussions of the withdrawal of thioridazine","volume":"36","author":"\u00c1lvarez IB","year":"2008","journal-title":"Actas Esp Psiquiatr"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638230410001654549"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0140-6736(09)60742-X","article-title":"11\u2010year follow\u2010up of mortality in patients with schizophrenia: a polulation\u2010based cohort study (FIN11 study)","volume":"374","author":"Tiihonen J","year":"2009","journal-title":"Lancet"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-9338(98)80049-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.1.79"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-200015030-00001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/10401230109147385"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2007.07.012"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.3346","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.3346","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.3346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T13:13:29Z","timestamp":1752844409000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.3346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,2]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1002\/pds.3346"],"URL":"https:\/\/doi.org\/10.1002\/pds.3346","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,2]]}}}