{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:13:10Z","timestamp":1791252790638,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T00:00:00Z","timestamp":1372032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the prevalence of adverse drug reactions (ADRs) occurring in patients with Alzheimer's disease (AD) or other dementia in France.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional multicentre study was conducted by the French network of the 31 regional pharmacovigilance centres on a given day. The subjects were selected by random draw to be a representative sample of French patients with dementia: consultations of dementia clinics, nursing\u2010homes, acute and long care geriatric units, rehabilitation care geriatric units. The staff of each medical structure together with that of the pharmacovigilance centre defined a day for including the patients. Socio\u2010demographic data, history, ADR and drugs given were registered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 1332 subjects included, 51.1% living at home, 48.8% in institutions, aged 82.0\u2009\u00b1\u20098.0\u2009years (46\u2013108); 61.3% suffered from AD. Mean number of drugs was 6.3\u2009\u00b1\u20093.1. Anti\u2010dementia drugs were given to 66.4% subjects. ADR prevalence was 5.0% (95% CI: 3.9\u20136.2) without a significant difference between at home and institutionalized patients. ADR consisted of gastro\u2010intestinal (23.2%), central nervous system (17.4%) and psychiatric disorders (8.7%). Of the ADR, 31.9% were serious, and 47.8% preventable. The drugs most often involved were anti\u2010dementia (28.9%), cardio\u2010vascular (28.9%) and psychotropic drugs (26.4%, anxiolytics, hypnotics, antidepressants, neuroleptics).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This national scale study showed that iatrogenesis in patients with AD and related dementia can at times be serious and preventable. Therefore, special attention is required when prescribing psychotropic and anti\u2010dementia drugs, as they are frequently used and induce half of the ADR in this population. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.3471","type":"journal-article","created":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T06:52:39Z","timestamp":1372056759000},"page":"952-960","source":"Crossref","is-referenced-by-count":44,"title":["Adverse drug reactions in patients with Alzheimer's disease and related dementia in France: a national multicentre cross\u2010sectional study"],"prefix":"10.1002","volume":"22","author":[{"given":"Marie\u2010Laure","family":"Laroche","sequence":"first","affiliation":[{"name":"Regional Centre of Pharmacovigilance, Pharmacology\u2013Toxicology\u2013Pharmacovigilance Unit University Hospital  Limoges 87042 France"},{"name":"EA 6310 HAVAE University of Limoges  Limoges 87025 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Christine","family":"Perault\u2010Pochat","sequence":"additional","affiliation":[{"name":"Regional Centre of Pharmacovigilance, Clinical 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