{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:57:34Z","timestamp":1791086254308,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T00:00:00Z","timestamp":1376265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Anti\u2010dopaminergic anti\u2010emetics (ADA) use for the treatment of nausea associated with gastroenteritis (GE) can be considered inappropriate, as their effects are not supported by evidence of clinical efficacy and can potentially induce serious adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study quantifies the suboptimal consumption of ADA attributable to seasonal GE epidemics in France and its cost.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>GE epidemiological data were collected and transmitted by the general practitioners (GPs) of <jats:italic>Sentinelles<\/jats:italic> network. Epidemic periods were identified by periodic regression. Drug sales data were obtained from pharmacies, and costs data were obtained from the French National Social Security. The ADA use and costs incurred by seasonal GE epidemics were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the epidemic periods considered in this study, the median age of patients seen by GPs for GE was 24 years old. During each epidemic, a sale increase by 14% for domperidone, by 15% for metoclopramide and 30% for metopimazine was observed. The average cost attributable to seasonal GE epidemic was 5\u2009030\u2009000 Euros, of which 2\u2009160\u2009000 Euros were incurred by the French National Social Security.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Linking epidemiological databases helped to identify and quantify inappropriate ADA prescriptions. GE treatment guidelines should be disseminated more widely. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.3486","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T07:05:18Z","timestamp":1376291118000},"page":"1080-1085","source":"Crossref","is-referenced-by-count":10,"title":["Estimating the excess of inappropriate prescriptions of anti\u2010dopaminergic anti\u2010emetics during acute gastroenteritis epidemics in France"],"prefix":"10.1002","volume":"22","author":[{"given":"Victoire","family":"Roussel","sequence":"first","affiliation":[{"name":"Assistance Publique H\u00f4pitaux de Paris, Service de M\u00e9decine Interne H\u00f4pital Ambroise Par\u00e9  Boulogne Billancourt F\u201092100 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Tritz","sequence":"additional","affiliation":[{"name":"Assistance Publique H\u00f4pitaux de Paris, Service de Pharmacie H\u00f4pital Ambroise Par\u00e9  Boulogne Billancourt F\u201092100 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Souty","sequence":"additional","affiliation":[{"name":"UMR\u2010S 707 Inserm  F\u201075012 Paris France"},{"name":"UPMC Universit\u00e9 Paris 6  F\u201075012 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Turbelin","sequence":"additional","affiliation":[{"name":"UMR\u2010S 707 Inserm  F\u201075012 Paris France"},{"name":"UPMC Universit\u00e9 Paris 6  F\u201075012 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Arena","sequence":"additional","affiliation":[{"name":"UMR\u2010S 707 Inserm  F\u201075012 Paris France"},{"name":"UPMC Universit\u00e9 Paris 6  F\u201075012 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Lambert","sequence":"additional","affiliation":[{"name":"IMS Health  Puteaux F\u201092800 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