{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:47:43Z","timestamp":1790819263397,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,3]],"date-time":"2013-08-03T00:00:00Z","timestamp":1375488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To describe the prescription of antibiotics before, during and after pregnancy, and the trends over a 16\u2010year period in the Netherlands, and to determine whether they were prescribed according to national guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The IADB (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/iadb.nl\">http:\/\/iadb.nl<\/jats:ext-link>) contains prescriptions dispensed by community pharmacies in the Netherlands. We extracted information on 18\u2009873 pregnancies for 14\u2009969 women between 1994 and 2009, focusing on antibiotics dispensed in the four trimesters before conception to two trimesters after birth (nine trimesters in total). We calculated trends in prescription rates during pregnancy and over time, and also compared the prescription of antibiotics in the Netherlands with safety category based on the Australian Drug Evaluation Committee.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During pregnancy 20.8% of the women were prescribed at least one antibiotic. The \u2018beta\u2010lactam antibacterials\/penicillins\u2019 group and the specific antibiotic amoxicillin were most commonly prescribed in the nine trimesters covered. The prescription rate of the \u2018other antibacterials\u2019 group during pregnancy increased over the years, in contrast to that of the \u2018sulphonamides\/trimethoprim\u2019 group, which decreased. In total, 2.0% of pregnancies were exposed to a \u2018potentially harmful\u2019 antibiotic and 0.8% to a \u2018harmful\u2019 antibiotic. Compared with the period before conception, \u2018safe\u2019 antibiotics were prescribed more often during pregnancy than the other groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>One in five women was prescribed at least one antibiotic during pregnancy in the Netherlands, which is comparable with rates in other European countries. Our results suggest that antibiotics appear to be prescribed to pregnant women generally in accordance with national recommendations. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.3492","type":"journal-article","created":{"date-parts":[[2013,8,3]],"date-time":"2013-08-03T07:07:23Z","timestamp":1375513643000},"page":"60-68","source":"Crossref","is-referenced-by-count":77,"title":["Antibiotics prescribed before, during and after pregnancy in the Netherlands: a drug utilization study"],"prefix":"10.1002","volume":"23","author":[{"given":"Linda","family":"de Jonge","sequence":"first","affiliation":[{"name":"University of Groningen, University Medical Center Groningen Department of Genetics, Eurocat Registration Northern Netherlands  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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