{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:15:58Z","timestamp":1761513358278},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,9,22]],"date-time":"2013-09-22T00:00:00Z","timestamp":1379808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>HIV\u2010infected patients may be at particular risk for acetaminophen\u2010induced hepatotoxicity, but acetaminophen use in the context of liver injury has been incompletely examined among HIV\u2010infected patients. Among a sample of HIV\u2010infected patients, we aimed to determine acetaminophen exposure, assess the cross\u2010sectional association between acetaminophen exposure and advanced hepatic fibrosis, and determine whether factors associated with acetaminophen exposure varied by HCV status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a cross\u2010sectional analysis of the Veterans Aging Cohort Study. Advanced hepatic fibrosis was defined as a FIB\u20104\u2009&gt;\u20093.25, a composite score calculated based on age, alanine aminotransferase, aspartate aminotransferase, and platelet count. Multivariable ordered polytomous logistic regression was used to determine the association between FIB\u20104 status and acetaminophen exposure stratified by HCV status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among HIV\u2010infected patients (<jats:italic>n<\/jats:italic>\u2009=\u200914\u2009885), 31% received at least one acetaminophen prescription. Among those receiving acetaminophen, acetaminophen overuse was common among both HIV\u2010monoinfected and HIV\/HCV\u2010coinfected patients (846 [31%] vs 596[32%], <jats:italic>p<\/jats:italic>\u2009=\u20090.79). After stratifying by HCV status, those with evidence of advanced liver fibrosis were equally likely to be exposed to acetaminophen. Furthermore, HIV\u2010monoinfected patients with an alcohol use disorder were more likely to have acetaminophen overuse (OR [95%CI]\u2009=\u20091.56 [1.21\u20132.02]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Strategies to minimize acetaminophen exposure, especially for HIV\u2010monoinfected patients, are warranted. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.3517","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T21:53:44Z","timestamp":1381528424000},"page":"1352-1356","source":"Crossref","is-referenced-by-count":10,"title":["Acetaminophen receipt among HIV\u2010infected patients with advanced hepatic fibrosis"],"prefix":"10.1002","volume":"22","author":[{"given":"E. Jennifer","family":"Edelman","sequence":"first","affiliation":[{"name":"Department of Medicine Yale University, School of Medicine  New Haven CT USA"},{"name":"Center for Interdisciplinary Research on AIDS Yale University School of Public Health  New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsha S.","family":"Gordon","sequence":"additional","affiliation":[{"name":"VA Connecticut Healthcare System  West Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Vincent Lo","family":"Re","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine University of Pennsylvania  Philadelphia PA USA"},{"name":"Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine University of Pennsylvania  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Skanderson","sequence":"additional","affiliation":[{"name":"VA Connecticut Healthcare System  West Haven CT USA"},{"name":"VA Pittsburgh Healthcare System  Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Fiellin","sequence":"additional","affiliation":[{"name":"Department of Medicine Yale University, School of Medicine  New Haven CT USA"},{"name":"Center for Interdisciplinary Research on AIDS Yale University School of Public Health  New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy C.","family":"Justice","sequence":"additional","affiliation":[{"name":"Department of Medicine Yale University, School of Medicine  New Haven CT USA"},{"name":"Center for Interdisciplinary Research on AIDS Yale University School of Public Health  New Haven CT USA"},{"name":"VA Connecticut Healthcare System  West Haven CT 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