{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T21:33:01Z","timestamp":1772832781242,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T00:00:00Z","timestamp":1378944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High\u2010grade cervical dysplasia or cervical intraepithelial neoplasia grade 2 or worse has been widely used as a surrogate endpoint in cervical cancer screening or prevention trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To identify high\u2010grade cervical dysplasia and cervical cancer, we developed claims\u2010based algorithms that incorporated a combination of diagnosis and procedure codes using the billing data in an electronic medical records database and assessed the validity of the algorithms in an independent administrative claims database. We calculated the positive predictive value (PPV) with the 95% confidence interval (CI) of each algorithm, using new cytologic or pathologic diagnosis of cervical intraepithelial neoplasia 2 or 3, carcinoma <jats:italic>in situ<\/jats:italic>, or cervical cancer as the gold standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Having \u22651 diagnosis code for high\u2010grade cervical dysplasia or cervical cancer had a PPV of 57.1% (95%CI, 54.7\u201359.5%). By requiring \u22652 diagnoses for high\u2010grade cervical dysplasia or cervical cancer, separated by 7\u201330\u2009days, the PPV increased to 60.2% (95%CI, 53.9\u201366.1%). At least two diagnoses and a procedure code within a month from the first diagnosis date yielded a PPV of 80.7% (95%CI, 73.6\u201386.2%). The algorithms had greater PPVs in identifying prevalent high\u2010grade cervical dysplasia or cervical cancer. Overall, the PPVs of these algorithms were similar or slightly lower in the external claims data than in the sample used to derive the algorithms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Use of \u22652 diagnosis codes in combination with a procedure code appears to be a valid tool for studying high\u2010grade cervical dysplasia and cervical cancer in both electronic medical record and administrative claims databases. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.3520","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T08:57:53Z","timestamp":1378976273000},"page":"1239-1244","source":"Crossref","is-referenced-by-count":24,"title":["Validation of claims\u2010based algorithms for identification of high\u2010grade cervical dysplasia and cervical cancer"],"prefix":"10.1002","volume":"22","author":[{"given":"Seoyoung C.","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics Brigham and Women's Hospital\/Harvard Medical School  Boston MA USA"},{"name":"Division of Rheumatology, Immunology and Allergy Brigham and Women's Hospital  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria G.","family":"Gillet","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics Brigham and Women's Hospital\/Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Feldman","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Dana\u2010Farber Cancer Institute  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huichuan","family":"Lii","sequence":"additional","affiliation":[{"name":"Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sengwee","family":"Toh","sequence":"additional","affiliation":[{"name":"Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey S.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey N.","family":"Katz","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Immunology and Allergy Brigham and Women's Hospital  Boston MA USA"},{"name":"Department of Orthopedic Surgery Brigham and Women's Hospital\/Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel H.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics Brigham and Women's Hospital\/Harvard Medical School  Boston MA USA"},{"name":"Division of Rheumatology, Immunology and Allergy Brigham and Women's Hospital  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Schneeweiss","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics Brigham and Women's Hospital\/Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"e_1_2_7_4_1","unstructured":"FerlayJ ShinH BrayF et al.Cervical Cancer Incidence and Mortality Worldwide in 2008. Cancer Fact Sheet 2008 [cited October 2 2012]; GLOBOCAN 2008 v2.0: Available from:http:\/\/globocan.iarc.fr\/factsheets\/cancers\/cervix.asp"},{"key":"e_1_2_7_5_1","volume-title":"SEER Stat Fact Sheets: Cervix Uteri. SEER Cancer Statistics Review, 1975\u20132009","author":"Howlader N","year":"2012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.5858\/2004-128-1224-BIARRP"},{"key":"e_1_2_7_8_1","first-page":"17","article-title":"Cervical human papillomavirus infection and intraepithelial neoplasia: a review","volume":"21","author":"Mitchell MF","year":"1996","journal-title":"J Natl Cancer Inst Monogr"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.047"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2004.10.012"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061741"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000192397.41191.fb"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc702"},{"key":"e_1_2_7_14_1","unstructured":"Partners HealthCare System.Research Patient Data Registry (RPDR)2012[cited 2013 July 22]; Available from:http:\/\/rc.partners.org\/rpdr"},{"key":"e_1_2_7_15_1","unstructured":"HMO Research Network.Members [cited 2013 July 22 ]; Available from:http:\/\/www.hmoresearchnetwork.org\/members.htm"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.08.002"},{"key":"e_1_2_7_17_1","first-page":"137","volume-title":"Modern Epidemiology","author":"Rothman KJ","year":"2008"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.3520","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.3520","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.3520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T22:26:13Z","timestamp":1696890373000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.3520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,12]]},"references-count":16,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1002\/pds.3520"],"URL":"https:\/\/doi.org\/10.1002\/pds.3520","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,12]]}}}