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To prevent false\u2010positive results, we consider a bootstrap\u2010enhanced version of the Lasso. To highlight the most stable results, we extensively examine sensitivity to the choice of referent window.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Antiepileptics, benzodiazepine hypnotics, anxiolytics, antidepressants, antithrombotic agents, mineral supplements, drugs used in diabetes, antiparkinsonian treatment, and several cardiovascular drugs showed suspected associations with road traffic accident involvement or accident responsibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results, in relation to other findings in the literature, provide new insight and may generate new hypotheses on the association between prescription drugs use and impaired driving ability. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.3539","type":"journal-article","created":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T11:44:43Z","timestamp":1382096683000},"page":"140-151","source":"Crossref","is-referenced-by-count":16,"title":["Variable selection on large case\u2010crossover data: application to a registry\u2010based study of prescription drugs and road traffic crashes"],"prefix":"10.1002","volume":"23","author":[{"given":"Marta","family":"Avalos","sequence":"first","affiliation":[{"name":"Univ. Bordeaux, ISPED Centre INSERM U897\u2010Epidemiologie\u2010Biostatistique F\u201033000 Bordeaux France"},{"name":"INSERM, ISPED Centre INSERM U897\u2010Epidemiologie\u2010Biostatistique F\u201033000 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludivine","family":"Orriols","sequence":"additional","affiliation":[{"name":"Univ. 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