{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:44:53Z","timestamp":1773387893860,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T00:00:00Z","timestamp":1389916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swedish Council on Health Technology Assessment"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this study was to analyse prescription refill, re\u2010hospitalisation, total mortality, mortality because of suicide and attempted suicide among patients who were taking various types of antipsychotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population\u2010based cohort study analysed all patients (<jats:italic>n<\/jats:italic>=26\u2009046) in Sweden who had been treated for schizophrenia from 2006 to 2009 with regard to re\u2010hospitalisation and prescription refill for various types of antipsychotic treatment. A case\u2010control study nested within the cohort analysed all\u2010cause mortality, mortality because of suicide and attempted suicide in relation to antipsychotic use. The study adjusted for history of hospitalisation for psychiatric and medical care, attempted suicide and use of antidepressants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Aripiprazole users were the only ones who showed significantly lower all\u2010cause risks of death, but so few events occurred among users of this relatively new drug that the results should be interpreted with caution. Clozapine users showed lower odds of death by suicide (odds ratio [OR]\u2009=\u20090.45 [95%CI 0.20\u20130.98]) and of attempted suicide (OR\u2009=\u20090.44 [0.28\u20130.70]) than haloperidol users after adjustment for age, sex and year of discharge. Olanzapine users showed approximately the same favourable pattern. Patients who used clozapine were most likely to refill prescriptions and had lower rates of re\u2010hospitalisation. Only one death and 23 cases of agranulocytosis were reported compared with 223 suicides and 831 suicide attempts. An etiologic fraction calculation suggests that the use of clozapine rather than traditional drugs could have prevented 95 suicide attempts during the period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clozapine and olanzapine reduce the risk of suicide, attempted suicide and re\u2010hospitalisation. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.3567","type":"journal-article","created":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T11:59:35Z","timestamp":1389959975000},"page":"290-298","source":"Crossref","is-referenced-by-count":64,"title":["Mortality, attempted suicide, re\u2010hospitalisation and prescription refill for clozapine and other antipsychotics in Sweden\u2014a register\u2010based study"],"prefix":"10.1002","volume":"23","author":[{"given":"Gunilla","family":"Ringb\u00e4ck Weitoft","sequence":"first","affiliation":[{"name":"Swedish National Board of Health and Welfare  Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Berglund","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Clinical Sciences Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva A.","family":"Lindstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Uppsala University Hospital  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Swedish Council on Health Technology Assessment  Stockholm Sweden"},{"name":"Department of Learning, Informatics, Management, and Ethics Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Salmi","sequence":"additional","affiliation":[{"name":"Swedish National Board of Health and Welfare  Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e5ns","family":"Ros\u00e9n","sequence":"additional","affiliation":[{"name":"Swedish Council on Health Technology Assessment  Stockholm Sweden"},{"name":"Department of Learning, Informatics, Management, and Ethics Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,17]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60742-X"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38881.382755.2F"},{"key":"e_1_2_16_4_1","doi-asserted-by":"crossref","unstructured":"Asenjo LobosC KomossaK Rummel\u2010KlugeC et al.Clozapine versus other typical antipsychotics for schizophrenia. 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