{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:29:17Z","timestamp":1789194557964,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T00:00:00Z","timestamp":1400025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of science and technology of China","award":["2008ZX10002-007,2008ZX10002-018 and 2008ZX10002-025"],"award-info":[{"award-number":["2008ZX10002-007,2008ZX10002-018 and 2008ZX10002-025"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81373105"],"award-info":[{"award-number":["81373105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association between calcium channel blockers (CCBs) and increased risk of breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using terms related to breast cancer and CCB, we searched PubMed, Embase, and Web of Science for studies on CCB use and the associated risk of breast cancer published before July 2013. Two evaluators independently selected observational studies on the basis of predetermined selection criteria, and 11 studies were included in the meta\u2010analysis. Summary estimates were obtained using fixed\u2010effects or random\u2010effects models as appropriate, and subgroup analyses, sensitivity analyses, and publication bias tests were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our meta\u2010analysis consisted of 11 studies, including four case\u2013controls, two nested case\u2013controls, and five cohort studies. The odds ratios (ORs) of the association between CCB use and breast cancer were 1.11 (95% confidence interval [CI] 0.93\u20131.33) overall, 1.04 (95%CI 0.92\u20131.18) for prospective studies, and 1.33 (95%CI 0.79\u20132.25) for retrospective studies. There was a positive association between immediate\u2010release CCB use and risk of breast cancer (OR 1.88, 95%CI 1.37\u20132.60).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is no evidence that CCB use is associated with an increased risk of breast cancer. However, there may be a positive association between immediate\u2010release CCB use and risk of breast cancer, but given the current preference for use of sustained\u2010release CCB, the potential clinical impact of this association is limited. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.3645","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T11:40:06Z","timestamp":1400067606000},"page":"711-718","source":"Crossref","is-referenced-by-count":29,"title":["Association between calcium channel blockers and breast cancer: a meta\u2010analysis of observational studies"],"prefix":"10.1002","volume":"23","author":[{"given":"Qi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Health Statistics Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Changzheng Hospital Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhong","sequence":"additional","affiliation":[{"name":"Graduate 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