{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:08:36Z","timestamp":1765728516607},"reference-count":61,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T00:00:00Z","timestamp":1407715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"French Health Ministry"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The goal of this study is to compare patient\u2010reported quality of life (PRQOL) evolution between two groups of end\u2010stage renal disease patients with secondary hyperparathyroidism (SHPT). The first with a cinacalcet prescription within 3\u2009months after a diagnosis of SHPT (early group) and a second group of patients with a later or no cinacalcet prescription (nonearly group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>From 2009 to 2012, we conducted a multicenter pharmaco\u2010epidemiologic study in Lorraine region (France) including all consecutive patients on maintenance dialysis for at least 3\u2009months with a diagnosis of SHPT (PTH\u2009&gt;\u2009500\u2009pg\/ml or first cinacalcet prescription). PRQOL was estimated using the Kidney Disease Quality Of Life\u2010Short Form questionnaire, at baseline and at 6 and 12\u2009months follow\u2010up. Change in PRQOL was compared between the groups and adjusted with a propensity score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 124 patients: 44 in the early group and 80 in the nonearly group. The mental component summary score was lower in the early group, at baseline (43.6\u2009\u00b1\u20096.6 vs 46.6\u2009\u00b1\u20097.6; <jats:italic>p<\/jats:italic>\u2009=\u20090.030), and at the follow\u2010up assessment (42.6\u2009\u00b1\u20096.9 vs 45.7\u2009\u00b1\u20097.9; <jats:italic>p<\/jats:italic>\u2009=\u20090.033). We found no difference between the groups in change in PRQOL, for all dimensions, even after adjustment with the propensity score. Mean serum alkaline phosphatase levels were normal in both groups at baseline (80.9\u2009\u00b1\u200932.5 vs 95.1\u2009\u00b1\u200939.6; <jats:italic>p<\/jats:italic>\u2009=\u20090.41).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cinacalcet prescription immediately following diagnosis of SHPT does not seem to be associated with better PRQOL evolution at 1\u2009year. Mean serum alkaline phosphatase levels suggest that physicians should consider waiting for another PTH assay result before starting cinacalcet in case of a PTH rise. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.3683","type":"journal-article","created":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T11:48:01Z","timestamp":1407757681000},"page":"187-196","source":"Crossref","is-referenced-by-count":6,"title":["Influence on quality of life from an early cinacalcet prescription for secondary hyperparathyroidism in dialysis"],"prefix":"10.1002","volume":"24","author":[{"given":"Pierre","family":"Filipozzi","sequence":"first","affiliation":[{"name":"Department of Nephrology, Dialysis, and Transplantation CHU Nancy  F\u201054 511 Vandoeuvre\u2010les\u2010Nancy France"},{"name":"CHU Nancy, P\u00f4le S2R Epid\u00e9miologie et Evaluation Cliniques  Nancy F\u201054 000 France"},{"name":"INSERM CIC\u2010EC, CIC 1433  Nancy F\u201054 000 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole","family":"Ayav","sequence":"additional","affiliation":[{"name":"CHU Nancy, P\u00f4le S2R Epid\u00e9miologie et Evaluation Cliniques  Nancy F\u201054 000 France"},{"name":"INSERM CIC\u2010EC, CIC 1433  Nancy F\u201054 000 France"},{"name":"Universit\u00e9 de Lorraine CIC\u2010EC, CIC 1433  Nancy F\u201054 000 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Line","family":"Erpelding","sequence":"additional","affiliation":[{"name":"CHU Nancy, P\u00f4le S2R Epid\u00e9miologie et Evaluation Cliniques  Nancy F\u201054 000 France"},{"name":"INSERM CIC\u2010EC, CIC 1433  Nancy F\u201054 000 France"},{"name":"Universit\u00e9 de Lorraine CIC\u2010EC, CIC 1433  Nancy F\u201054 000 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mich\u00e8le","family":"Kessler","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Transplantation CHU Nancy  F\u201054 511 Vandoeuvre\u2010les\u2010Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Brunaud","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary, Digestive and Endocrine Surgery CHU Nancy  F\u201054 511 Vandoeuvre\u2010les\u2010Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Frimat","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Transplantation CHU Nancy  F\u201054 511 Vandoeuvre\u2010les\u2010Nancy France"},{"name":"Universit\u00e9 de Lorraine, Universit\u00e9 Paris Descartes APEMAC, EA4360  Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,11]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Network and epidemiologic information in nephrology: kidney report 2011[Internet]. 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