{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:39:56Z","timestamp":1791632396676,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"FDA","award":["HHSF223201000009I"],"award-info":[{"award-number":["HHSF223201000009I"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Stevens\u2013Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) carry a high mortality risk. While identifying clinical and genetic risk factors for these conditions has been hindered by their rarity, large electronic health databases hold promise for identifying large numbers of cases for study, especially with the introduction in 2008 of ICD\u20109 codes more specific for these conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study is to estimate the validity of ICD\u20109 codes for ascertaining SJS\/TEN in 12 collaborating research units in the USA, covering almost 60 million lives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From the electronic databases at each site, we ascertained potential cases of SJS\/TEN using ICD\u20109 codes. At five sites, a subset of medical records was abstracted and standardized criteria applied by board\u2010certified dermatologists to adjudicate diagnoses. Multivariate logistic regression was used to identify factors independently associated with validated SJS\/TEN cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 56\u2009591 potential cases of SJS\/TEN were identified. A subset of 276 charts was selected for adjudication and 39 (of the 276) were confirmed as SJS\/TEN. Patients with the ICD\u20109 codes introduced after 2008 were more likely to be confirmed as cases (OR 3.32; 95%CI 0.82, 13.47) than those identified in earlier years. Likelihood of case status increased with length of hospitalization. Applying the probability of case status to the 56\u2009591 potential cases, we estimated 475\u2013875 to be valid SJS\/TEN cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Newer ICD\u20109 codes, along with length of hospitalization, identified patients with a high likelihood of SJS\/TEN. This is important for identification of subjects for future pharmacogenomics studies. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.3778","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T20:59:59Z","timestamp":1429909199000},"page":"684-692","source":"Crossref","is-referenced-by-count":49,"title":["Identification of Stevens\u2013Johnson syndrome and toxic epidermal necrolysis in electronic health record databases"],"prefix":"10.1002","volume":"24","author":[{"given":"Robert L.","family":"Davis","sequence":"first","affiliation":[{"name":"University of Tennessee Health Sciences Center  Memphis TN USA"},{"name":"Kaiser Permanente Georgia  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia A.","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Georgia  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam M.","family":"Asgari","sequence":"additional","affiliation":[{"name":"Kaiser 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