{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:33:22Z","timestamp":1787582002711,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T00:00:00Z","timestamp":1447027200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T00:00:00Z","timestamp":1447027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology of Taiwan","doi-asserted-by":"crossref","award":["NSC 102-2628-B-006-003-MY"],"award-info":[{"award-number":["NSC 102-2628-B-006-003-MY"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiol Drug Saf"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1002\/pds.3903","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T08:52:40Z","timestamp":1447059160000},"page":"123-132","source":"Crossref","is-referenced-by-count":12,"title":["Comparative risk of oral ulcerations among antipsychotics users - population-based retrospective cohort study"],"prefix":"10.1002","volume":"25","author":[{"given":"Edward Chia-Cheng","family":"Lai","sequence":"first","affiliation":[{"name":"Duke Clinical Research Institute; Durham NC USA"},{"name":"Department of Medicine; Duke University School of Medicine; Durham NC USA"},{"name":"School of Pharmacy and Institute of Clinical Pharmacy and Pharmaceutical Sciences; National Cheng Kung University; Tainan Taiwan"},{"name":"Health Outcome Research Center; National Cheng Kung University; Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Yang","family":"Hsieh","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Institute of Clinical Pharmacy and Pharmaceutical Sciences; National Cheng Kung University; Tainan Taiwan"},{"name":"Department of Neurology; Tainan Sin-Lau Hospital; Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monera B.","family":"Wong","sequence":"additional","affiliation":[{"name":"Geriatric Medicine Unit; Massachusetts General Hospital; Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swu-Jane","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Administration, College of Pharmacy; University of Illinois at Chicago; Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Kuang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry; National Cheng Kung University Hospital; Tainan Taiwan"},{"name":"College of Medicine; National Cheng Kung University; Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yea-Huei","family":"Kao Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Institute of Clinical Pharmacy and Pharmaceutical Sciences; National Cheng Kung University; Tainan Taiwan"},{"name":"Health Outcome Research Center; National Cheng Kung University; Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soko","family":"Setoguchi","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute; Durham NC USA"},{"name":"Department of Medicine; Duke University School of Medicine; Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,9]]},"reference":[{"key":"10.1002\/pds.3903-BIB0001|pds3903-cit-0001","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/0021-9681(78)90058-9","article-title":"A questionnaire for the assessment of leisure time physical activities","volume":"31","author":"Taylor","year":"1978","journal-title":"J Chronic Dis"},{"key":"10.1002\/pds.3903-BIB0002|pds3903-cit-0002","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0749-3797(18)31107-3","article-title":"Exercise patterns in a population of older adults","volume":"5","author":"McPhillips","year":"1989","journal-title":"Am J Prev Med"},{"key":"10.1002\/pds.3903-BIB0003|pds3903-cit-0003","doi-asserted-by":"crossref","first-page":"S498","DOI":"10.1097\/00005768-200009001-00009","article-title":"Compendium of physical activities: an update of activity codes and MET intensities","volume":"32","author":"Ainsworth","year":"2000","journal-title":"Med Sci Sports Exerc"},{"key":"10.1002\/pds.3903-BIB0004|pds3903-cit-0004","doi-asserted-by":"crossref","first-page":"520","DOI":"10.2105\/AJPH.91.3.520c","article-title":"Support the framework for action on oral health in America: a report of the Surgeon General","volume":"91","year":"2001","journal-title":"Am J Public Health"},{"key":"10.1002\/pds.3903-BIB0005|pds3903-cit-0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1741-2358.1999.00011.x","article-title":"The impact of oral health on stated ability to eat certain foods; findings from the National Diet and Nutrition Survey of Older People in Great Britain","volume":"16","author":"Sheiham","year":"1999","journal-title":"Gerodontology"},{"key":"10.1002\/pds.3903-BIB0006|pds3903-cit-0006","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1111\/j.1532-5415.2007.01391.x","article-title":"Association between aspects of oral health-related quality of life and body mass index in community-dwelling older adults","volume":"55","author":"Makhija","year":"2007","journal-title":"J Am Geriatr Soc"},{"key":"10.1002\/pds.3903-BIB0007|pds3903-cit-0007","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1752-7325.2000.tb03339.x","article-title":"Oral health and nutrition in older people","volume":"60","author":"Walls","year":"2000","journal-title":"J Public Health Dent"},{"key":"10.1002\/pds.3903-BIB0008|pds3903-cit-0008","doi-asserted-by":"crossref","first-page":"171","DOI":"10.4103\/0970-9290.29868","article-title":"Oral health status and treatment needs in institutionalized psychiatric patients: one year descriptive cross sectional study","volume":"17","author":"Kumar","year":"2006","journal-title":"Indian J Dent Res : official publication of Indian Society for Dental Research"},{"key":"10.1002\/pds.3903-BIB0009|pds3903-cit-0009","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1034\/j.1601-0825.2003.03967.x","article-title":"Drug effects on salivary glands: dry mouth","volume":"9","author":"Scully","year":"2003","journal-title":"Oral Dis"},{"key":"10.1002\/pds.3903-BIB0010|pds3903-cit-0010","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/gps.930020409","article-title":"Sulpiride and placebo in depressed elderly outpatients: A double-blind study","volume":"2","author":"Kivel\u00e4","year":"1987","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1002\/pds.3903-BIB0011|pds3903-cit-0011","doi-asserted-by":"crossref","first-page":"e89795","DOI":"10.1371\/journal.pone.0089795","article-title":"Detecting potential adverse reactions of sulpiride in schizophrenic patients by prescription sequence symmetry analysis","volume":"9","author":"Lai","year":"2014","journal-title":"Plos One"},{"key":"10.1002\/pds.3903-BIB0012|pds3903-cit-0012","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2334\/josnusd.54.85","article-title":"Prevalence of oral mucosal disorders in institutionalized and non-institutionalized psychiatric patients: a study from AVBR Hospital in central India","volume":"54","author":"Dangore-Khasbage","year":"2012","journal-title":"J Oral Sci"},{"key":"10.1002\/pds.3903-BIB0013|pds3903-cit-0013","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/gps.930020409","article-title":"Sulpiride and placebo in depressed elderly outpatients: A double-blind study","volume":"2","author":"Kivel\u00e4","year":"1987","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1002\/pds.3903-BIB0014|pds3903-cit-0014","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1067\/moe.2001.118478","article-title":"Prevalence of subjective dry mouth and burning mouth in hospitalized elderly patients and outpatients in relation to saliva, medication, and systemic diseases","volume":"92","author":"Pajukoski","year":"2001","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1002\/pds.3903-BIB0015|pds3903-cit-0015","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/154411130401500405","article-title":"Adverse drug reactions in the orofacial region","volume":"15","author":"Scully","year":"2004","journal-title":"Crit Rev Oral Biol Med : an official publication of the American Association of Oral Biologists"},{"key":"10.1002\/pds.3903-BIB0016|pds3903-cit-0016","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/schbul\/sbq042","article-title":"Second-generation antipsychotic drugs and extrapyramidal side effects: a systematic review and meta-analysis of head-to-head comparisons","volume":"38","author":"Rummel-Kluge","year":"2012","journal-title":"Schizophr Bull"},{"key":"10.1002\/pds.3903-BIB0017|pds3903-cit-0017","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0140-6736(08)61764-X","article-title":"Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis","volume":"373","author":"Leucht","year":"2009","journal-title":"Lancet"},{"key":"10.1002\/pds.3903-BIB0018|pds3903-cit-0018","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/schbul\/sbs002","article-title":"Effectiveness of sulpiride in adult patients with schizophrenia","volume":"39","author":"Lai","year":"2013","journal-title":"Schizophr Bull"},{"key":"10.1002\/pds.3903-BIB0019|pds3903-cit-0019","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ajp.2014.08.002","article-title":"Antipsychotic treatment of schizophrenia: An update","volume":"11","author":"Bruijnzeel","year":"2014","journal-title":"Asian J psychiatr"},{"key":"10.1002\/pds.3903-BIB0020|pds3903-cit-0020","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1517\/13543784.2010.515586","article-title":"Quetiapine: novel uses in the treatment of depressive and anxiety disorders","volume":"19","author":"Ravindran","year":"2010","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1002\/pds.3903-BIB0021|pds3903-cit-0021","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/pds.2087","article-title":"Validation of the National Health Insurance Research Database with ischemic stroke cases in Taiwan","volume":"20","author":"Cheng","year":"2011","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1002\/pds.3903-BIB0022|pds3903-cit-0022","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1528-1167.2011.03332.x","article-title":"Geographic variation in the age- and gender-specific prevalence and incidence of epilepsy: analysis of Taiwanese National Health Insurance-based data","volume":"53","author":"Chen","year":"2012","journal-title":"Epilepsia"},{"key":"10.1002\/pds.3903-BIB0023|pds3903-cit-0023","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1053\/j.gastro.2010.06.067","article-title":"Histamine2-receptor antagonists are an alternative to proton pump inhibitor in patients receiving clopidogrel","volume":"139","author":"Wu","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1002\/pds.3903-BIB0024|pds3903-cit-0024","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/sj.clpt.6100069","article-title":"Risk of extrapyramidal syndrome in schizophrenic patients treated with antipsychotics: a population-based study","volume":"81","author":"Yang","year":"2007","journal-title":"Clin Pharmacol Ther"},{"key":"10.1002\/pds.3903-BIB0025|pds3903-cit-0025","first-page":"743","article-title":"Comparative study on the influence of psychotropic agents on stress induced lesions of the gastric mucosa","volume":"22","author":"Mollmann","year":"1972","journal-title":"Arzneimittelforschung"},{"key":"10.1002\/pds.3903-BIB0026|pds3903-cit-0026","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1034\/j.1601-0825.2002.01789.x","article-title":"Oral mucosal conditions in elderly dental patients","volume":"8","author":"Jainkittivong","year":"2002","journal-title":"Oral Dis"},{"key":"10.1002\/pds.3903-BIB0027|pds3903-cit-0027","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1093\/schbul\/sbu001","article-title":"Dose equivalents for second-generation antipsychotics: the minimum effective dose method","volume":"40","author":"Leucht","year":"2014","journal-title":"Schizophr Bull"},{"key":"10.1002\/pds.3903-BIB0028|pds3903-cit-0028","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1097\/EDE.0b013e3181a663cc","article-title":"High-dimensional propensity score adjustment in studies of treatment effects using health care claims data","volume":"20","author":"Schneeweiss","year":"2009","journal-title":"Epidemiology (Cambridge, Mass)"},{"key":"10.1002\/pds.3903-BIB0029|pds3903-cit-0029","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1097\/MLR.0b013e31806518ac","article-title":"Using inverse probability-weighted estimators in comparative effectiveness analyses with observational databases","volume":"45","author":"Curtis","year":"2007","journal-title":"Med Care"},{"key":"10.1002\/pds.3903-BIB0030|pds3903-cit-0030","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1754-4505.1991.tb01726.x","article-title":"Oral health care for the patient with schizophrenia","volume":"11","author":"Friedlander","year":"1991","journal-title":"Spec Care Dentist : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry"},{"key":"10.1002\/pds.3903-BIB0031|pds3903-cit-0031","first-page":"501","article-title":"Common oral lesions: Part I. Superficial mucosal lesions","volume":"75","author":"Gonsalves","year":"2007","journal-title":"Am Fam Physician"},{"key":"10.1002\/pds.3903-BIB0032|pds3903-cit-0032","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.seizure.2012.10.009","article-title":"Antipsychotics and seizures: higher risk with atypicals?","volume":"22","author":"Lertxundi","year":"2013","journal-title":"Seizure : the journal of the British Epilepsy Association"},{"key":"10.1002\/pds.3903-BIB0033|pds3903-cit-0033","first-page":"Cd000967","article-title":"Quetiapine for schizophrenia","volume":"2","author":"Srisurapanont","year":"2000","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1002\/pds.3903-BIB0034|pds3903-cit-0034","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/JCP.0b013e31819a91f1","article-title":"Systematic overview of Cochrane reviews for anticholinergic effects of antipsychotic drugs","volume":"29","author":"Ozbilen","year":"2009","journal-title":"J Clin Psychopharmacol"},{"key":"10.1002\/pds.3903-BIB0035|pds3903-cit-0035","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2165\/00003495-200161010-00011","article-title":"Olanzapine: an updated review of its use in the management of schizophrenia","volume":"61","author":"Bhana","year":"2001","journal-title":"Drugs"},{"key":"10.1002\/pds.3903-BIB0036|pds3903-cit-0036","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.schres.2007.03.006","article-title":"Risperidone-induced sialorrhea responsive to biperiden treatment","volume":"93","author":"Panagiotidis","year":"2007","journal-title":"Schizophr Res"},{"key":"10.1002\/pds.3903-BIB0037|pds3903-cit-0037","doi-asserted-by":"crossref","DOI":"10.1111\/odi.12209","article-title":"The antipsychotic amisulpride: ultrastructural evidence of its secretory activity in salivary glands","author":"Loy","year":"2013","journal-title":"Oral Dis"},{"key":"10.1002\/pds.3903-BIB0038|pds3903-cit-0038","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/j.1601-0825.2012.01926.x","article-title":"Atypical antipsychotics - effects of amisulpride on salivary secretion and on clozapine-induced sialorrhea","volume":"18","author":"Godoy","year":"2012","journal-title":"Oral Dis"},{"key":"10.1002\/pds.3903-BIB0039|pds3903-cit-0039","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1358\/dot.2005.41.6.893628","article-title":"Drug-induced sialorrhea","volume":"41","author":"Freudenreich","year":"2005","journal-title":"Drugs Today (Barc)"},{"key":"10.1002\/pds.3903-BIB0040|pds3903-cit-0040","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s12603-012-0007-2","article-title":"Xerostomia and medication: a cross-sectional study in long-term geriatric wards","volume":"16","author":"Desoutter","year":"2012","journal-title":"J Nutr Health Aging"},{"key":"10.1002\/pds.3903-BIB0041|pds3903-cit-0041","first-page":"Cd006569","article-title":"Aripiprazole versus other atypical antipsychotics for schizophrenia","volume":"1","author":"Khanna","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1002\/pds.3903-BIB0042|pds3903-cit-0042","doi-asserted-by":"crossref","first-page":"503","DOI":"10.4103\/2141-9248.139284","article-title":"Xerostomia due to systemic disease: a review of 20 conditions and mechanisms","volume":"4","author":"Mortazavi","year":"2014","journal-title":"Ann Med Health Sci Res"},{"key":"10.1002\/pds.3903-BIB0043|pds3903-cit-0043","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1159\/000253147","article-title":"Xerostomia after acute stroke","volume":"28","author":"Kerr","year":"2009","journal-title":"Cerebrovasc Dis"},{"key":"10.1002\/pds.3903-BIB0044|pds3903-cit-0044","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/adj.12143","article-title":"Oral mucosal lesions: findings from the Australian National Survey of Adult Oral Health","volume":"59","author":"Do","year":"2014","journal-title":"Aust Dent J"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.3903","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.3903","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/pds.3903\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T23:46:59Z","timestamp":1625356019000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.3903"}},"subtitle":["Antipsychotics and Oral Ulcerations"],"short-title":[],"issued":{"date-parts":[[2015,11,9]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"URL":"https:\/\/doi.org\/10.1002\/pds.3903","archive":["Portico"],"relation":{},"ISSN":["1053-8569"],"issn-type":[{"value":"1053-8569","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11,9]]}}}