{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T15:56:40Z","timestamp":1765727800388},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T00:00:00Z","timestamp":1453161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Leading Talents of Science in Shanghai 2010","award":["022"],"award-info":[{"award-number":["022"]}]},{"name":"Key Discipline Construction of Evidence-Based Public Health in Shanghai","award":["12GWZX0602"],"award-info":[{"award-number":["12GWZX0602"]}]},{"name":"Key Program of Shanghai Soft Science Research","award":["14692101700"],"award-info":[{"award-number":["14692101700"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>There has been much controversy over the use of angiotensin\u2010converting enzyme inhibitors\/angiotensin receptor blockers (ACEIs\/ARBs) on patients with renal dysfunction. The purpose of this study was to summarize the evidence regarding the effect of ACEIs\/ARBs administration on mortality in patients with nondialysis\u2010dependent chronic kidney disease (CKD) by using a meta\u2010analytic approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the PubMed, Embase, and Web of Science databases for studies on the effect of ACEIs\/ARBs administration on mortality in patients with nondialysis\u2010dependent CKD published before March 2015. Summary effect estimates with 95% confidence intervals were derived using the random\u2010effects model, no matter whether the heterogeneity between the included studies was of statistical significance or not. Subgroup analyses, sensitivity analyses, and publication bias tests were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Up to 25 March 2015, 10 cohort studies were included in this meta\u2010analysis. The hazard risk of the association between ACEIs\/ARBs administration and overall mortality was 0.83 (95% confidence interval 0.78\u20130.87) using a random\u2010effects model with no heterogeneity (heterogeneity test <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200943.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.067) and publication bias (Egger's test, <jats:italic>p<\/jats:italic>\u2009=\u20090.763). The subgroup was divided according to estimated glomerular filtration rate, duration of follow\u2010up, Newcastle\u2013Ottawa Scale star, and proportion of patients with common complications including heart failure, diabetes mellitus, and hypertension. Improved survival outcomes were observed in all subgroups analysis. Sensitivity analysis proved that overall estimated effect was robust.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This meta\u2010analysis suggested that the use of ACEIs\/ARBs in patients with nondialysis\u2010dependent CKD was associated with improved survival. However, randomized studies are needed to confirm these findings and further establish causal relationship. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.3941","type":"journal-article","created":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T02:00:51Z","timestamp":1453255251000},"page":"503-511","source":"Crossref","is-referenced-by-count":12,"title":["The effect of angiotensin\u2010converting enzyme inhibitor\/angiotensin receptor blocker use on mortality in patients with chronic kidney disease: a meta\u2010analysis of observational studies"],"prefix":"10.1002","volume":"25","author":[{"given":"Yuchen","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Health Statistics Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Changhai Hospital, Second Military Medical University  Shanghai 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