{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T10:06:34Z","timestamp":1783764394769,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T00:00:00Z","timestamp":1469664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"EU","award":["QLK4-CT-2001-00343"],"award-info":[{"award-number":["QLK4-CT-2001-00343"]}]},{"name":"EU","award":["QLK4-CT-2001-2812"],"award-info":[{"award-number":["QLK4-CT-2001-2812"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this study was to give an overview of the prevalence of contact allergy to active ingredients and excipients of topical medications across Europe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of data collected by the European Surveillance System on Contact Allergies (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.essca-dc.org\">www.essca\u2010dc.org<\/jats:ext-link>) with substances applied to consecutively patch tested patients, 2009\u20132012, in 54 departments in 12 European countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In view of the varying composition of the baseline series used in the previously mentioned departments and countries, between 58\u2009833 (lanolin alcohols) and 16\u2009498 patients (sodium metabisulfite) were patch tested with the topical agents covered in this study. Among these, positive (allergic) reactions were most commonly observed to sodium metabisulfite (3.12% positive), followed by propolis (2.48%), Compositae mix (1.73%), lanolin alcohols (1.65%) and caine mix III (benzocaine, cinchocaine and tetracaine; 1.27%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Several of the substances warrant routine screening for contact allergy, i.e. patch testing in a baseline series. However, in view of a vast number of other topical agents, additional patch testing with the suspect topical drug preparations (including natural remedies and cosmetics) is warranted. In the event of a positive test to the (pharmaceutical) product, single ingredients should be tested individually to precisely identify the hapten(s). Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.4064","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T06:42:40Z","timestamp":1469688160000},"page":"1305-1312","source":"Crossref","is-referenced-by-count":48,"title":["Contact allergy to ingredients of topical medications: results of the European Surveillance System on Contact Allergies (ESSCA), 2009\u20132012"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4498-3710","authenticated-orcid":false,"given":"Wolfgang","family":"Uter","sequence":"first","affiliation":[{"name":"Department of Medical Informatics, Biometry and Epidemiology University of Erlangen\/N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radoslaw","family":"Spiewak","sequence":"additional","affiliation":[{"name":"Department of Experimental Dermatology and Cosmetology, Faculty of Pharmacy Jagiellonian University Medical College  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Dermatology Churchill Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chapel Allerton Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"S\u00e1nchez P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario la Princesa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Schnuch","sequence":"additional","affiliation":[{"name":"Information Network of Departments of Dermatology (IVDK) University Medicine G\u00f6ttingen  G\u00f6ttingen 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