{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T13:21:40Z","timestamp":1778592100735,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,20]],"date-time":"2016-11-20T00:00:00Z","timestamp":1479600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health, Social Policy and Equality (Spanish Government)","award":["EC11-251"],"award-info":[{"award-number":["EC11-251"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this study was to assess effectiveness and safety of antithrombotics for stroke prevention in non\u2010valvular atrial fibrillation in real\u2010use conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used a population\u2010based retrospective cohort study. Information emerges from SIDIAP, a database containing anonymized information from electronic health records from 274 primary healthcare centres of the Catalan Health Institute, Catalonia (Spain), with a reference population of 5\u2009835\u2009000 people.<\/jats:p><jats:p>Population includes all adults with a new diagnosis of non\u2010valvular atrial fibrillation registered in SIDIAP from 2007 to 2012.<\/jats:p><jats:p>The main outcome of antithrombotics' effectiveness was stroke. The main outcomes of safety were cerebral and gastrointestinal haemorrhages. We also estimated all\u2010cause mortality. We used multivariable Cox proportional hazard models to examine association between antithrombotic treatment and main outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 22\u2009205 subjects with non\u2010valvular atrial fibrillation; 40.8% initiated on vitamin K antagonists (VKA), 33.4% on antiplatelets and 25.8% untreated. We found stroke\u2010risk reduction with VKA, hazard ratio (HR) 0.72 (95% confidence interval (CI), 0.58\u20130.91), also seen in patients with CHADS<jats:sub>2<\/jats:sub>\u2009\u2265\u20092, HR 0.65 (95%CI, 0.49\u20130.86), and CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc\u2009\u2265\u20092, HR 0.66 (95%CI, 0.52\u20130.84). We observed a higher risk of digestive bleeding with antiplatelets, HR 1.32 (95%CI, 1.01\u20131.73). Both VKA and antiplatelets were associated with reduction of all\u2010cause mortality risk; HR 0.55 (95%CI, 0.49\u20130.62) and HR 0.89 (95%CI, 0.80\u20130.97), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study found a stroke\u2010risk reduction associated with VKA and an increased risk of gastrointestinal bleeding associated with platelet\u2010aggregation inhibitors in comparison with untreated patients. Both antithrombotic groups showed a reduction in all\u2010cause mortality. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.4137","type":"journal-article","created":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T03:12:44Z","timestamp":1479697964000},"page":"97-107","source":"Crossref","is-referenced-by-count":11,"title":["Effectiveness and safety of drugs used for stroke prevention in a cohort of non\u2010valvular atrial fibrillation patients from a primary care electronic database"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3750-9233","authenticated-orcid":false,"given":"Maria","family":"Giner\u2010Soriano","sequence":"first","affiliation":[{"name":"Institut Universitari d'Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol (IDIAP Jordi Gol)  Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona  Bellaterra (Cerdanyola del Vall\u00e8s) 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