{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:25:40Z","timestamp":1791440740610,"version":"4.3.3"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this study was to examine the association between angiotensin converting enzyme (ACE) inhibitor use and the risk of acute pancreatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Information on all 4966 cases hospitalized in 2008\u20132010 for acute pancreatitis was retrieved from the Finnish national registers on hospital discharges and prescriptions. A total of 24\u00a0788 age and sex\u2010matched population\u2010based controls were randomly selected using density sampling. ACE inhibitor use between 1 January 2003 and the index date were determined by the date of hospitalization for acute pancreatitis among the cases. The incidence rate ratios of acute pancreatitis not diagnosed as biliary or alcohol\u2010induced were modeled by conditional logistic regression and adjusted for comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1276 (26%) cases and 3946 (16%) controls had been exposed to ACE inhibitors. The use of ACE inhibitors was associated with an increased incidence rate of acute pancreatitis (odds ratio [OR] 1.76, 95% confidence interval [CI] 1.59\u20131.95). The increase was slightly higher among current new users (OR 1.86, 95%CI 1.65\u20132.09) and somewhat lower among current prevalent (OR 1.54, 95%CI 1.35\u20131.75) and former users (OR 1.51, 95%CI 1.31\u20131.74).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Angiotensin converting enzyme inhibitor use seems to be associated with a moderately increased risk of acute pancreatitis. Copyright \u00a9 2017 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.4179","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T07:16:40Z","timestamp":1488352600000},"page":"853-857","source":"Crossref","is-referenced-by-count":15,"title":["ACE inhibitors and the risk of acute pancreatitis\u2014a population\u2010based case\u2013control study"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7842-6552","authenticated-orcid":false,"given":"Jaana","family":"Kuoppala","sequence":"first","affiliation":[{"name":"Finnish Medicines Agency Fimea  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Enlund","sequence":"additional","affiliation":[{"name":"Finnish Medicines Agency Fimea  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jukka","family":"Pulkkinen","sequence":"additional","affiliation":[{"name":"Kuopio University Hospital  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Kastarinen","sequence":"additional","affiliation":[{"name":"Social Insurance Institution of Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Jyrkk\u00e4","sequence":"additional","affiliation":[{"name":"Finnish Medicines Agency Fimea  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pertti","family":"Happonen","sequence":"additional","affiliation":[{"name":"Finnish Medicines Agency Fimea  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu","family":"Paajanen","sequence":"additional","affiliation":[{"name":"Kuopio University Hospital  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198805123181914"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000173929.60115.b4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01485.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520600761676"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12461"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C270"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7549.1072"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2007.10.007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-012-0245-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200831100-00002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1277-3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.303"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.307"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3858"},{"key":"e_1_2_8_16_1","unstructured":"WHOCC.ATC\/DDD: international language for drug utilization research.WHO Collaborating Centre for Drug Statistics Methodology.http:\/\/www.whocc.no(accessed 25 May 2016)."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02728.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-002-0471-4"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.01.038"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.4179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.4179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T11:34:03Z","timestamp":1696505643000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.4179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1002\/pds.4179"],"URL":"https:\/\/doi.org\/10.1002\/pds.4179","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]}}}