{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T10:20:52Z","timestamp":1763202052140,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T00:00:00Z","timestamp":1490918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"GlaxoSmithKline Biologicals SA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of the study is to evaluate whether primary care electronic medical records (EMRs) from patients with severe asthma can be used to identify allergic bronchopulmonary aspergillosis (ABPA) cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional feasibility study was conducted in adults with active and severe asthma registered with the Clinical Practice Research Datalink. A set of keywords flagged terms potentially indicative of ABPA in free\u2010text comments of patients' EMRs to produce a grid on the basis of keywords' hit or miss. The grid was examined for occurrence and concurrence of keywords to discern patterns of concurrence potentially indicative of an underlying diagnosis of ABPA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analyses included 3\u00a0653\u00a0169 free\u2010text items from 21\u00a0054 patients. In total, 52 patients (0.25%) had at least one mention of \u2018ABPA\u2019 in their medical record; 67% of these patients also had a mention of \u2018aspergillus\/aspergillosis\u2019, 54% of \u2018bronchiectasis\u2019, 42% of \u2018itraconazole\u2019 and 62% of \u2018IgE\u2019. The term \u2018aspergillus\/aspergillosis\u2019 occurred with a proportion of 1.84% (<jats:italic>N<\/jats:italic>\u00a0=\u00a0387); 9% of these patients also had a mention of \u2018ABPA\u2019, and the remaining 91% were potential additional cases of ABPA. From the observed concurrence of keywords, we were able to devise a potential algorithm to identify cases with varying degrees of specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that analysis of free text within asthmatic patients' EMRs may be used to identify potential cases of ABPA. This could be an efficient approach to identify rare conditions and to quantify their potential burden. \u00a9 2017 The Authors. Pharmacoepidemiology &amp; Drug Safety Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.4204","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T11:00:02Z","timestamp":1490958002000},"page":"785-791","source":"Crossref","is-referenced-by-count":17,"title":["Identifying rare diseases using electronic medical records: the example of allergic bronchopulmonary aspergillosis"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3563-4583","authenticated-orcid":false,"given":"Andrew","family":"Maguire","sequence":"first","affiliation":[{"name":"OXON Epidemiology Ltd  London UK"},{"name":"Department of Biomedical Sciences University of Alcala de Henares  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle E.","family":"Johnson","sequence":"additional","affiliation":[{"name":"OXON Epidemiology Ltd  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Denning","sequence":"additional","affiliation":[{"name":"National Aspergillosis Centre University Hospital of South Manchester, The University of Manchester, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germano L.C.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Vaccine Discovery and Development GSK Vaccines  Wavre Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Cassidy","sequence":"additional","affiliation":[{"name":"Vaccine Discovery and Development GSK Vaccines  Wavre Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200908-086AL"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1295716"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12141"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-204"},{"key":"e_1_2_8_7_1","unstructured":"National Institute for Health and Care Excellence.Asthma quality standard. 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