{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:41:45Z","timestamp":1785451305567,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T00:00:00Z","timestamp":1497571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Canadian Drug Safety and Effectiveness Research Network CIHR","award":["ETG92247"],"award-info":[{"award-number":["ETG92247"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The anticonvulsant pregabalin is increasingly prescribed for pain, seizures, and psychiatric disorders. Although evidence suggests pregabalin can cause edema and heart failure, its cardiac safety profile in clinical practice is unknown. We sought to examine the risk of heart failure among older patients receiving pregabalin compared to those receiving gabapentin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a population\u2010based cohort study of Ontarians aged 66 and older with a history of seizure who received pregabalin or gabapentin between April 2013 and March 2014. We used propensity scores to match patients commencing pregabalin to those commencing gabapentin. The primary outcome was an emergency department visit or hospitalization for heart failure within 90\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We studied 9855 patients who initiated pregabalin and an equal number treated with gabapentin. In the primary analysis, we found no difference in the risk of heart failure with pregabalin compared to gabapentin (1.2% versus 1.3%, hazard ratio of 0.77; 95% CI 0.58\u20101.03). Secondary analyses stratified for baseline history of heart failure yielded similar findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a large cohort of older patients with a seizure disorder, pregabalin was not associated with an increased risk of heart failure relative to gabapentin.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.4239","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T08:06:39Z","timestamp":1497600399000},"page":"1087-1092","source":"Crossref","is-referenced-by-count":20,"title":["Pregabalin and heart failure: <scp>A<\/scp> population\u2010based study"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8252-2034","authenticated-orcid":false,"given":"Joanne M.\u2010W.","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Medicine University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5441-2324","authenticated-orcid":false,"given":"Erin M.","family":"Macdonald","sequence":"additional","affiliation":[{"name":"The Institute for Clinical Evaluative Sciences  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9462-2016","authenticated-orcid":false,"given":"Jin","family":"Luo","sequence":"additional","affiliation":[{"name":"The Institute for Clinical Evaluative Sciences  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1468-1965","authenticated-orcid":false,"given":"Tara","family":"Gomes","sequence":"additional","affiliation":[{"name":"The Institute for Clinical Evaluative Sciences  Toronto ON Canada"},{"name":"The Leslie Dan Faculty of Pharmacy University of Toronto  Toronto ON Canada"},{"name":"Li Ka Shing Knowledge Institute St. Michael's Hospital  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6984-8953","authenticated-orcid":false,"given":"Tony","family":"Antoniou","sequence":"additional","affiliation":[{"name":"The Institute for Clinical Evaluative Sciences  Toronto ON Canada"},{"name":"Li Ka Shing Knowledge Institute St. Michael's Hospital  Toronto ON Canada"},{"name":"Department of Family and Community Medicine University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5199-6344","authenticated-orcid":false,"given":"Muhammad M.","family":"Mamdani","sequence":"additional","affiliation":[{"name":"The Institute for Clinical Evaluative Sciences  Toronto ON Canada"},{"name":"The Leslie Dan Faculty of Pharmacy University of Toronto  Toronto ON Canada"},{"name":"Li Ka Shing Knowledge Institute St. Michael's Hospital  Toronto ON Canada"},{"name":"Department of Health Policy, Management and Evaluation University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0368-4212","authenticated-orcid":false,"given":"David N.","family":"Juurlink","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Toronto  Toronto ON Canada"},{"name":"The Institute for Clinical Evaluative Sciences  Toronto ON Canada"},{"name":"Department of Health Policy, Management and Evaluation University of Toronto  Toronto ON Canada"},{"name":"The Sunnybrook Research Institute  Toronto ON Canada"},{"name":"Department of Pediatrics University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/11536200-000000000-00000"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2007.03.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.16.12237"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d25b34"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2006.11.006"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e3282fb7629"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2008.03196.x"},{"key":"e_1_2_9_9_1","unstructured":"MedEffect Canada.Canadian vigilance adverse reaction. 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