{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:13:21Z","timestamp":1784002401683,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T00:00:00Z","timestamp":1496880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fondo d\u2019Ateneo per la Ricerca","award":["2014-ATE-0232"],"award-info":[{"award-number":["2014-ATE-0232"]}]},{"name":"Laboratory of Healthcare Research and Pharmacoepidemiology"},{"name":"Italian Ministry of the Education, University and Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Untreated depression and antidepressant use during pregnancy may have negative consequences for births. There are still conflicting data on the potential harmful effects of prenatal antidepressant treatment on child health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the relationship between the use of antidepressant medication during pregnancy and selected neonatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population\u2010based cohort study including 9825 deliveries exposed to an antidepressant between 9\u00a0months before last menstrual date through to delivery, from January 2005 to December 2010 in the Lombardy region of Italy, was conducted. We evaluated the prevalence ratio (PR) of low Apgar score, small for gestational age, intrauterine hypoxia and birth asphyxia, neonatal convulsion, and other respiratory conditions, among infants born to mothers exposed to an antidepressant during pregnancy using log\u2010binomial regression analysis. Fine stratification was applied to the propensity score to account for all potential confounders. Sensitivity and subgroup analyses restricted to specific types of antidepressant, time of exposure, and women with vaginal deliveries and full\u2010term births were also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 33.4% of women filled at least one prescription during pregnancy. Compared to infants born to mothers with exposure to antidepressants only before pregnancy, those with exposure to antidepressants during pregnancy had an increased prevalence ratio of a low Apgar score (PR, 1.63, 95% CI, 1.01\u20102.61), intrauterine hypoxia and birth asphyxia (aPR, 1.37, 1.08\u20101.73), neonatal convulsion (aPR, 2.81, 1.07\u20107.36), and other respiratory condition (aPR, 1.24, 1.00\u20101.52). Results were similar in the sensitivity and subgroup analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Use of antidepressants during pregnancy may have an increased risk for several neonatal outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.4242","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T09:52:37Z","timestamp":1496915557000},"page":"1100-1108","source":"Crossref","is-referenced-by-count":33,"title":["Use of antidepressant medication in pregnancy and adverse neonatal outcomes: A population\u2010based investigation"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3700-780X","authenticated-orcid":false,"given":"Anna","family":"Cantarutti","sequence":"first","affiliation":[{"name":"Department of Statistics and Quantitative Methods, Division of Biostatistics, Epidemiology and Public Health, Laboratory of Healthcare Research and Pharmacoepidemiology University of Milano\u2010Bicocca  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Merlino","sequence":"additional","affiliation":[{"name":"Operative Unit of Territorial Health Services Region of Lombardy  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9365-0413","authenticated-orcid":false,"given":"Carlo","family":"Giaquinto","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1034-8444","authenticated-orcid":false,"given":"Giovanni","family":"Corrao","sequence":"additional","affiliation":[{"name":"Department of Statistics and Quantitative Methods, Division of Biostatistics, Epidemiology and Public Health, Laboratory of Healthcare Research and Pharmacoepidemiology University of Milano\u2010Bicocca  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-006-0177-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.01.033"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.8.898"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0018168"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/11.3.329"},{"issue":"2","key":"e_1_2_9_7_1","first-page":"145","article-title":"Cigarette smoking in pregnancy: observational prospective study in three towns of Tuscany region (Central Italy)","volume":"37","author":"Nutini S","year":"2013","journal-title":"Epidemiol Prev"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7189.1012"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70240-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181ba0632"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052744"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20773"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.2333"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.19.2372"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00073"},{"issue":"11","key":"e_1_2_9_16_1","first-page":"978","article-title":"Antidepressants in pregnancy: a systematic review","volume":"44","author":"Udechuku A","year":"2010","journal-title":"Aust N Z J Psychiatry"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.051421"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.158.4.312"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.684"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102153440701"},{"key":"e_1_2_9_21_1","unstructured":"BrandJPL.Development implementation and evaluation of multiple imputation strategies for the statistical analysis of incomplete data sets.1999."},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280206074463"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4067"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168115"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000595"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1200"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050664"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.12.2055"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.02.019"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.08081170"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2013.08.002"},{"issue":"12","key":"e_1_2_9_32_1","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1001\/jama.1990.03450120053028","article-title":"Depression and the dynamics of smoking. A national perspective","volume":"264","author":"Anda RF","year":"1990","journal-title":"JAMA"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/her\/14.5.611"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14213"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04858"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.4242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.4242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:01:00Z","timestamp":1696359660000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.4242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,8]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1002\/pds.4242"],"URL":"https:\/\/doi.org\/10.1002\/pds.4242","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,8]]}}}