{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T18:16:32Z","timestamp":1773944192093,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["HHSF223201400030I"],"award-info":[{"award-number":["HHSF223201400030I"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","award":["HHSF223200910006I"],"award-info":[{"award-number":["HHSF223200910006I"]}],"id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Sentinel Distributed Database (SDD) is a large database of patient\u2010level administrative health care records, primarily derived from insurance claims and electronic health records, and is sponsored by the US Food and Drug Administration for medical product safety evaluations. Acute myocardial infarction (AMI) is a common study endpoint for drug safety studies that rely on health records from the SDD and other administrative databases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>In this chart validation study, we report on the positive predictive value (PPV) of inpatient International Classification of Diseases, Ninth Revision, Clinical Modification AMI administrative diagnosis codes (410.x1 and 410.x0) in the SDD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>As part of an assessment of thromboembolic adverse event risk following treatment with intravenous immune globulin, charts were obtained for 103 potential post\u2013intravenous immune globulin AMI cases. Charts were abstracted by trained nurses and physician\u2010adjudicated based on prespecified diagnostic criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Acute myocardial infarction status could be determined for 89 potential cases. The PPVs for the inpatient AMI diagnoses recorded in the SDD were 75% overall (95% CI, 65\u201084%), 93% (95% CI, 78\u201099%) for principal\u2010position diagnoses, 88% (95% CI, 72\u201097%) for secondary diagnoses, and 38% (95% CI, 20\u201059%) for position\u2010unspecified diagnoses (eg, diagnoses originating from separate physician claims associated with an inpatient stay). Of the confirmed AMI cases, demand ischemia was the suspected etiology more often for those coded in secondary or unspecified positions (72% and 40%, respectively) than for principal\u2010position AMI diagnoses (21%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The PPVs for principal and secondary AMI diagnoses were high and similar to estimates from prior chart validation studies. Position\u2010unspecified diagnosis codes were less likely to represent true AMI cases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.4398","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T09:46:45Z","timestamp":1518688005000},"page":"398-404","source":"Crossref","is-referenced-by-count":24,"title":["Chart validation of inpatient <scp>ICD\u20109\u2010CM<\/scp> administrative diagnosis codes for acute myocardial infarction (<scp>AMI<\/scp>) among intravenous immune globulin (<scp>IGIV<\/scp>) users in the <scp>S<\/scp>entinel <scp>D<\/scp>istributed <scp>D<\/scp>atabase"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5882-5388","authenticated-orcid":false,"given":"Eric M.","family":"Ammann","sequence":"first","affiliation":[{"name":"College of Public Health University of Iowa  Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marin L.","family":"Schweizer","sequence":"additional","affiliation":[{"name":"Iowa City VA Health Care System  Iowa City IA USA"},{"name":"University of Iowa Hospitals and Clinics  Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer G.","family":"Robinson","sequence":"additional","affiliation":[{"name":"College of Public Health University of Iowa  Iowa City IA USA"},{"name":"University of Iowa Hospitals and Clinics  Iowa City IA USA"},{"name":"Carver College of Medicine University of Iowa  Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayasheel O.","family":"Eschol","sequence":"additional","affiliation":[{"name":"University of Iowa Hospitals and Clinics  Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rami","family":"Kafa","sequence":"additional","affiliation":[{"name":"University of Iowa Hospitals and Clinics  Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saket","family":"Girotra","sequence":"additional","affiliation":[{"name":"University of Iowa Hospitals and Clinics  Iowa City IA USA"},{"name":"Carver College of Medicine University of Iowa  Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott K.","family":"Winiecki","sequence":"additional","affiliation":[{"name":"Center for Drug Evaluation and Research Food and Drug Administration  Silver Spring MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candace C.","family":"Fuller","sequence":"additional","affiliation":[{"name":"Harvard Medical School and Harvard Pilgrim Health Care Institute  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7478-4739","authenticated-orcid":false,"given":"Ryan M.","family":"Carnahan","sequence":"additional","affiliation":[{"name":"College of Public Health University of Iowa  Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-9657","authenticated-orcid":false,"given":"Charles E.","family":"Leonard","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine University of Pennsylvania  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3760-8557","authenticated-orcid":false,"given":"Cole","family":"Haskins","sequence":"additional","affiliation":[{"name":"College of Public Health University of Iowa  Iowa City IA USA"},{"name":"Carver College of Medicine University of Iowa  Iowa City IA USA"},{"name":"Medical Scientist Training Program University of Iowa  Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crystal","family":"Garcia","sequence":"additional","affiliation":[{"name":"Harvard Medical School and Harvard Pilgrim Health Care Institute  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1843-1955","authenticated-orcid":false,"given":"Elizabeth A.","family":"Chrischilles","sequence":"additional","affiliation":[{"name":"College of Public Health University of Iowa  Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,15]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Sentinel Coordinating Center Snapshot of Database Statistics.2017. 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