{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T04:19:01Z","timestamp":1777090741687,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T00:00:00Z","timestamp":1529971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","award":["HHSF223200910006I"],"award-info":[{"award-number":["HHSF223200910006I"]}],"id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To replicate the well\u2010established association between angiotensin\u2010converting enzyme inhibitors versus beta blockers and angioedema in the International Classification of Diseases, 10th Revision, Clinical Modification (ICD\u201010\u2010CM) era.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective, inception cohort study in a large insurance database formatted to the Sentinel Common Data Model. We defined study periods spanning the ICD\u20109\u2010CM era only, ICD\u201010\u2010CM era only, and ICD\u20109\u2010CM and ICD\u201010\u2010CM era and conducted simple\u2010forward mapping (SFM), simple\u2010backward mapping (SBM), and forward\u2010backward mapping (FBM) referencing the General Equivalence Mappings to translate the outcome (angioedema) and covariates from ICD\u20109\u2010CM to ICD\u201010\u2010CM. We performed propensity score (PS)\u2010matched and PS\u2010stratified Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the ICD\u20109\u2010CM and ICD\u201010\u2010CM eras spanning April 1 to September 30 of 2015 and 2016, there were 152\u00a0017 and 145\u00a0232 angiotensin\u2010converting enzyme inhibitor initiators and 115\u00a0073 and 116\u00a0652 beta\u2010blocker initiators, respectively. The PS\u2010matched HR was 4.19 (95% CI, 2.82\u20106.23) in the ICD\u20109\u2010CM era, 4.37 (2.92\u20106.52) in the ICD\u201010\u2010CM era using SFM, and 4.64 (3.05\u20107.07) in the ICD\u201010\u2010CM era using SBM and FBM. The PS\u2010matched HRs from the mixed ICD\u20109\u2010CM and ICD\u201010\u2010CM eras ranged from 3.91 (2.69\u20105.68) to 4.35 (3.33\u20105.70).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The adjusted HRs across different diagnostic coding eras and the use of SFM versus SBM and FBM produced numerically different but clinically similar results. Additional investigations as ICD\u201010\u2010CM data accumulate are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.4550","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T02:39:50Z","timestamp":1530067190000},"page":"829-838","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Assessing the impact of the new ICD\u201010\u2010CM coding system on pharmacoepidemiologic studies\u2014An application to the known association between angiotensin\u2010converting enzyme inhibitors and angioedema"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4957-8204","authenticated-orcid":false,"given":"Catherine A.","family":"Panozzo","sequence":"first","affiliation":[{"name":"Department of Population Medicine Harvard Pilgrim Health Care Institute and Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5428-9733","authenticated-orcid":false,"given":"Joshua J.","family":"Gagne","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine Brigham and Women's Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny W.","family":"Sun","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine Brigham and Women's Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Population Medicine Harvard Pilgrim Health Care Institute and Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talia 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