{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:34:41Z","timestamp":1790264081580,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T00:00:00Z","timestamp":1525737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate unintentional therapeutic medication errors associated with antidepressant and antipsychotic medications in the United States and expand current knowledge on the types of errors commonly associated with these medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of non\u2010health care facility unintentional therapeutic errors associated with antidepressant and antipsychotic medications was conducted using data from the National Poison Data System.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2000 to 2012, poison control centers received 207\u00a0670 calls reporting unintentional therapeutic errors associated with antidepressant or antipsychotic medications that occurred outside of a health care facility, averaging 15\u00a0975 errors annually. The rate of antidepressant\u2010related errors increased by 50.6% from 2000 to 2004, decreased by 6.5% from 2004 to 2006, and then increased 13.0% from 2006 to 2012. The rate of errors related to antipsychotic medications increased by 99.7% from 2000 to 2004 and then increased by 8.8% from 2004 to 2012. Overall, 70.1% of reported errors occurred among adults, and 59.3% were among females. The medications most frequently associated with errors were selective serotonin reuptake inhibitors (30.3%), atypical antipsychotics (24.1%), and other types of antidepressants (21.5%). Most medication errors took place when an individual inadvertently took or was given a medication twice (41.0%), inadvertently took someone else's medication (15.6%), or took the wrong medication (15.6%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides a comprehensive overview of non\u2010health care facility unintentional therapeutic errors associated with antidepressant and antipsychotic medications. The frequency and rate of these errors increased significantly from 2000 to 2012. Given that use of these medications is increasing in the US, this study provides important information about the epidemiology of the associated medication errors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.4554","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T02:36:47Z","timestamp":1525833407000},"page":"902-911","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antidepressant and antipsychotic medication errors reported to United States poison control centers"],"prefix":"10.1002","volume":"27","author":[{"given":"Alisha","family":"Kamboj","sequence":"first","affiliation":[{"name":"Center for Injury Research and Policy The Research Institute at Nationwide Children's Hospital  Columbus OH USA"},{"name":"College of Medicine The Ohio State University  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry A.","family":"Spiller","sequence":"additional","affiliation":[{"name":"College of Medicine The Ohio State University  Columbus OH USA"},{"name":"Central Ohio Poison Center Nationwide Children's Hospital  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel J.","family":"Casavant","sequence":"additional","affiliation":[{"name":"Center for Injury Research and Policy The Research Institute at Nationwide Children's Hospital  Columbus OH USA"},{"name":"College of Medicine The Ohio State University  Columbus OH USA"},{"name":"Central Ohio Poison Center Nationwide Children's Hospital  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thitphalak","family":"Chounthirath","sequence":"additional","affiliation":[{"name":"Center for Injury Research and Policy The Research Institute at Nationwide Children's Hospital  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nichole L.","family":"Hodges","sequence":"additional","affiliation":[{"name":"Center for Injury Research and Policy The Research Institute at Nationwide Children's Hospital  Columbus OH USA"},{"name":"College of Medicine The Ohio State University  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5838-8982","authenticated-orcid":false,"given":"Gary A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Center for Injury Research and Policy The Research Institute at Nationwide Children's Hospital  Columbus OH USA"},{"name":"College of Medicine The Ohio State University  Columbus OH USA"},{"name":"Child Injury Prevention Alliance  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp070190"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2014.953168"},{"key":"e_1_2_10_4_1","article-title":"Non\u2010health care facility anticonvulsant medication errors in the United States","author":"DeDonato EA","year":"2017","journal-title":"Hum Exp Toxicol"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2017.1337908"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028017714271"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1823"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-0309"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2016.1245421"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.436"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.7507"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2016.16050523"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03161207"},{"key":"e_1_2_10_14_1","unstructured":"American Association of Poison Control Centers.National Poison Data System (NPDS) Coding Users' Manual Version 3.1.2014.https:\/\/aapcc.s3.amazonaws.com\/pdfs\/member\u2010resources\/NPDS_Coding_Users_Manual_v3.1_07May2014.pdf. Accessed September 1 2017."},{"key":"e_1_2_10_15_1","unstructured":"US Census Bureau.National Intercensal Tables: 2000\u20132010 intercensal estimates by sex and age.https:\/\/www.census.gov\/data\/tables\/time\u2010series\/demo\/popest\/intercensal\u20102000\u20102010\u2010national.html. Accessed March 30 2017."},{"key":"e_1_2_10_16_1","unstructured":"US Census Bureau.Annual estimates of the resident population by single year of age and sex for the United States: April 1 2010\u2010July 1 2012.https:\/\/factfinder.census.gov\/faces\/tableservices\/jsf\/pages\/productview.xhtml?src=bkmk. Accessed March 30 2017."},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/15622970601178056"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0024780"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13m08443"},{"key":"e_1_2_10_20_1","unstructured":"PrattLA BrodyDJ GuQ.Antidepressant use in persons aged 12 and over: United States 2005\u20102008. NCHS data brief. Hyattsville MD: National Center for Health Statistics2011.https:\/\/www.cdc.gov\/nchs\/data\/databriefs\/db76.pdf. Accessed September 5 2017."},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2012.647"},{"key":"e_1_2_10_22_1","unstructured":"US Food and Drug Administration.Worsening depression and suicidality in patients being treated with antidepressants.2004.https:\/\/www.fda.gov\/Drugs\/DrugSafety\/PostmarketDrugSafetyInformationforPatientsandProviders\/ucm161696.htm. Accessed September 1 2017."},{"key":"e_1_2_10_23_1","unstructured":"US Food and Drug Administration.Labeling change request letter for antidepressant medications.2004.https:\/\/www.fda.gov\/Drugs\/DrugSafety\/InformationbyDrugClass\/ucm096352.htm. Accessed September 1 2017."},{"key":"e_1_2_10_24_1","unstructured":"Centers for Medicare and Medicaid Services.Antidepressant medications: use in pediatric patients.2015.https:\/\/www.cms.gov\/Medicare\u2010Medicaid\u2010Coordination\/Fraud\u2010Prevention\/Medicaid\u2010Integrity\u2010Education\/Pharmacy\u2010Education\u2010Materials\/Downloads\/ad\u2010pediatric\u2010factsheet11\u201014.pdf. Accessed September 1 2017."},{"issue":"7","key":"e_1_2_10_25_1","first-page":"601","article-title":"Impact of an antidepressant black box warning on suspected attempted suicides reported to poison control centers. In: Abstracts of the 2008 North American Congress of Clinical Toxicology Annual Meeting, September 11\u201316, 2008, Toronto, Canada","volume":"46","author":"Forrester M","year":"2008","journal-title":"Clin Toxicol."},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.593"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn3000923"},{"issue":"4","key":"e_1_2_10_28_1","first-page":"533","article-title":"Serotonin syndrome","volume":"13","author":"Volpi\u2010Abadie J","year":"2013","journal-title":"Ochsner J"},{"issue":"1","key":"e_1_2_10_29_1","first-page":"4","article-title":"Strategies for dosing and switching antipsychotics for optimal clinical management","volume":"69","author":"Buckley PF","year":"2008","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051688"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200424050-00004"},{"key":"e_1_2_10_32_1","unstructured":"IMS Institute for Healthcare Informatics.The use of medicines in the United States: review of 2011. Danbury CT: IMS Institute for Healthcare Informatics2012https:\/\/www.imshealth.com\/files\/web\/IMSH%20Institute\/Reports\/The%20Use%20of%20Medicines%20in%20the%20United%20States%202011\/IHII_Medicines_in_U.S_Report_2011.pdf. Accessed September 1 2017."},{"key":"e_1_2_10_33_1","unstructured":"Institute for Safe Medicine Practices.ISMP's List of Confused Drug Names.2015.http:\/\/www.ismp.org\/Tools\/confuseddrugnames.pdf. Accessed September 1 2017."},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199921020-00002"},{"issue":"27","key":"e_1_2_10_35_1","article-title":"Lithium side effects and toxicity: prevalence and management strategies","volume":"4","author":"Gitlin M","year":"2016","journal-title":"Int J Bipolar Disord."},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2011.08.004"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.4554","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.4554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T04:38:42Z","timestamp":1694666322000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.4554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,8]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1002\/pds.4554"],"URL":"https:\/\/doi.org\/10.1002\/pds.4554","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,8]]},"assertion":[{"value":"2017-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}