{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:32:51Z","timestamp":1789903971498,"version":"4.0.1"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T00:00:00Z","timestamp":1531872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2018,9]]},"abstract":"Abstract<\/jats:title>\n \n Purpose<\/jats:title>\n For studying drug utilization and safety in pregnancy based on administrative health care data, the reliable identification and classification of pregnancy outcomes in the data is essential. We aimed to optimize an existing algorithm for the identification and classification of pregnancy outcomes in the German Pharmacoepidemiological Research Database (GePaRD) with a particular focus on births.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We reconsidered all codes used by the original algorithm and applied it to data of GePaRD from 2006 to 2014. Longitudinal records of pregnancies were used to identify targets for enhancing the algorithm's specificity. We checked the plausibility of the results, eg, regarding the age distribution of persons with pregnancy outcomes. Based on 20 longitudinal records of pregnancies, we compared the outcome classification by clinical experts with the results of the modified algorithm.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Our algorithm identified 1\u00a0235\u00a0261 pregnancy outcomes in the database, with the majority (94%) being live births, classified as preterm (10%), term (78%), and (12%) births after the expected delivery date. The median age of pregnant women was 32\u00a0years (Q1 28; Q3 35). Implausible sequence of outcomes (for example, an induced abortion within a pregnancy categorized as ending in a live birth) were rare (0.03%). The case profile review by clinical experts resulted in the same outcome type and date as the algorithm in 95%.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Our algorithm led to plausible results regarding the identification and classification of pregnancy outcomes. It will be an important foundation for studies on drug utilization and drug safety during pregnancy based on GePaRD.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/pds.4588","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T04:59:57Z","timestamp":1531976397000},"page":"1005-1010","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Optimizing an algorithm for the identification and classification of pregnancy outcomes in German claims data"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2983-0222","authenticated-orcid":false,"given":"Nadine","family":"Wentzell","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology Leibniz Institute for Prevention Research and Epidemiology\u2014BIPS Bremen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Schink","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Leibniz Institute for Prevention Research and Epidemiology\u2014BIPS Bremen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Haug","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Leibniz Institute for Prevention Research and Epidemiology\u2014BIPS Bremen Germany"},{"name":"Faculty of Human and Health Sciences University of Bremen Bremen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Biometry and Data Management Leibniz Institute for Prevention Research and Epidemiology\u2014BIPS Bremen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke","family":"Niemeyer","sequence":"additional","affiliation":[{"name":"Department of Biometry and Data Management Leibniz Institute for Prevention Research and Epidemiology\u2014BIPS Bremen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Mikolajczyk","sequence":"additional","affiliation":[{"name":"Institute for Medical Epidemiology, Biometrics and Informatics Martin\u2010Luther\u2010University Halle\u2010Wittenberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2038"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3472"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3613"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3284"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3743"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3467"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1545"},{"key":"e_1_2_11_9_1","unstructured":"Institut f\u00fcr angewandte Qualit\u00e4tsf\u00f6rderung und Forschung im Gesundheitswesen GmbH (AQUA). 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