{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:29:32Z","timestamp":1740104972621,"version":"3.37.3"},"reference-count":12,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T00:00:00Z","timestamp":1537142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Drug side effects often lead to serious outcomes. Administration of second\u2010generation antipsychotics has resulted in diabetic ketoacidosis and diabetic coma leading to death. Therefore, pharmacists are required to collect information on clinical test values, determine the appropriate test timing, and coordinate with doctors for further clinical laboratory orders, all of which are labor\u2010intensive and time\u2010intensive tasks. In this study, we developed a side effect\u2010monitoring tool and aimed to clarify the influence and efficiency of monitoring side effects by using the tool in patients taking atypical antipsychotics in whom it is necessary to check clinical test values such as blood sugar levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We extracted clinical test values for patients treated with second\u2010generation antipsychotics from electronic medical records. The test values are automatically displayed in the side effect grade classification specified by CTCAE ver. 4.0. A database was constructed using scripts to provide alerts for the timing of clinical testing. The pharmacist used this tool to confirm clinical test values for patients taking medication and requested the physician to inspect orders based on the appropriate test timings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The management tool reduced the pharmacists' effort in collecting information on patients' prescription status and test values. It enabled patients to undergo tests at the appropriate time according to the progression of glucose metabolism and allowed for easy monitoring of side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results suggested that regardless of pharmacists' experience or skill, the introduction of this tool enables centralization of side effect monitoring and can contribute to proper drug use.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.4656","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T08:35:31Z","timestamp":1537173331000},"page":"1379-1384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Development and pharmacist\u2010mediated use of tools for monitoring atypical antipsychotic\u2010induced side effects related to blood glucose levels"],"prefix":"10.1002","volume":"27","author":[{"given":"Shunsuke","family":"Ishida","sequence":"first","affiliation":[{"name":"Department of Pharmacy Tokushima University Hospital  Tokushima 770\u20108503 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9376-2703","authenticated-orcid":false,"given":"Kenshi","family":"Takechi","sequence":"additional","affiliation":[{"name":"Clinical Trial Center for Developmental Therapeutics Tokushima University Hospital  Kuramoto Tokushima 770\u20108503 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Bando","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Tokushima University Hospital  Tokushima 770\u20108503 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Imanishi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Tokushima University Hospital  Tokushima 770\u20108503 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshito","family":"Zamami","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Tokushima University Hospital  Tokushima 770\u20108503 Japan"},{"name":"Department of Clinical Pharmacology and Therapeutics, Institute of Biomedical Sciences Tokushima University Graduate School  Tokushima 770\u20108503 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Chuma","sequence":"additional","affiliation":[{"name":"Clinical Trial Center for Developmental Therapeutics Tokushima University Hospital  Kuramoto Tokushima 770\u20108503 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Yanagawa","sequence":"additional","affiliation":[{"name":"Clinical Trial Center for Developmental Therapeutics Tokushima University Hospital  Kuramoto Tokushima 770\u20108503 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